新安医家“固本培元”法临床应用的数据分析

Data analysis on clinical application of Xin'an physicians' therapy of strengthening root and culturing original qi

目的分析新安医家运用"固本培元"法防治疾病的相关证治规律。方法选取12位新安医家的12本医籍,运用"固本培元"法共678条医案,建立数据库,运用SAS 8.0软件进行统计分析。结果医案中出现的症状主要为:脾气虚(腹胀、腹痛、便溏),肾气虚(腰膝酸软、眩晕、小便清长),肾阳虚(畏寒、下肢肿、腰痛);常用药物为人参、黄芪、白芍、茯苓、甘草、当归、陈皮、附子等。由数据挖掘出的基本方(KDD)为:人参、黄芪、白术、茯苓、甘草、白芍、当归、陈皮、半夏、柴胡、附子、肉桂、鹿角、紫河车、黄芩、知母。结论 "固本培元"法的治疗重点在于脾、肾并治,以补脾气、温补脾阳,补肾气、温补肾阳和督脉等为其基本治法。经过数理分析和数据挖掘,得到了一些有效药物,常见症状,常用药物和症状的组合及基本方。为今后临床治疗及实验研究提供了依据和研究线索,为新安医学的进一步研究提供了数据基础。

Objective To analyze the laws of treatment related to the therapy of strengthening root and culturing original qi applied by Xin＇an physicians.Methods Twelve medical books written by 12 Xin＇an physicians were selected and 678 medical records involved the therapy of strengthening root and culturing original qi.A database was established and the data were analyzed by using SAS8.0 software.Results The major symptoms in these medical records were spleen qi deficiency（abdominal distension,abdominal pain,and loose stools）,kidney qi deficiency（lumbar and knee debility,dizziness,and clear and abundant urine）,and kidney yang deficiency（chilly,lower limb swelling,and waist pain）.The medicinal used frequently included Renshen（Radix Ginseng）,Huangqi（Radix Astragali seu Hedysari）,Baishao（Radix Paeoniae Alba）,Fuling（Poria）,Gancao（Radix Glycyrrhizae）,Danggui（Radix Angelicae Sinensis）,Chenpi（Pericarpium Citri Reticulatae）,Fuzi（Radix Aconiti Carmichaeli） and so on.The basic formula mined by data（KDD） consisted of Renshen（Radix Ginseng）,Huangqi（Radix Astragali seu Hedysari）,Baizhu（Rhizoma Atractylodis Macrocephalae）,Fuling（Poria）,Gancao（Radix Glycyrrhizae）,Baishao（Radix Paeoniae Alba）,Danggui（Radix Angelicae Sinensis）,Chenpi（Pericarpium Citri Reticulatae）,Banxia（Rhizoma Pinelliae）,Chaihu（Radix Bupleuri）,Fuzi（Radix Aconiti Carmichaeli）,Rougui（Cortex Cinnamomi）,Lujiao（Cornu Cervi）,Ziheche（Placenta Hominis）,Huangqin（Radix Scutellariae） and Zhimu（Rhizoma Anemarrhenae）.Conclusion The focus of therapy of strengthening root and culturing original qi is to govern spleen and kidney together,and the basic therapy is to tonify spleen,warm and tonify spleen yang,tonify kidney,and warm and tonify kidney yang and Governor Vessel.Some effective medicinal,common symptoms,combination of common medicinal,combination of common symptoms and basic formula have been obtained through mathematical analysis and data mining.The discover from this study will provide basis and research clue for further clinical treatment and experimental studies,as well as data basis for development of Xin＇an medicine.