60例活动期溃疡性结肠炎血清IL-8水平及与大肠湿热证相关性分析

Correlation between serum IL-8 level and large intestinal damp-heat syndrome in 60 cases of active ulcerative colitis

目的观察活动期溃疡性结肠炎(ulcerative colitis,UC)及大肠湿热证UC患者血清白细胞介素-8(interleukin-8I,L-8)水平,探讨IL-8在UC发病中和大肠湿热导致UC发病中的作用。方法观察60例活动期UC患者(UC组),其中30例大肠湿热证UC患者(湿热组)3、0例非大肠湿热证UC患者(非湿热组)及16名健康体检者(健康组)血清IL-8的水平,并将大肠湿热证UC患者按UC病情严重程度分为轻度、中重度。比较UC组与健康组,湿热组、非湿热组与健康组及大肠湿热证轻度UC患者与中重度UC患者血清IL-8水平。结果 UC组血清IL-8水平高于健康组(P<0.05);湿热组血清IL-8水平显著高于非湿热组(P<0.01)及健康组(P<0.01),非湿热组血清IL-8水平稍高于健康组(P>0.05);在大肠湿热证的UC患者中,中重度UC患者血清IL-8水平显著高于轻度UC患者(P<0.05)。结论 IL-8在UC发病及大肠湿热导致UC的发病中起着重要作用,并且与大肠湿热证UC患者病情严重程度成正相关,可为活动期UC诊断及大肠湿热证UC患者的辨证及中医药治疗提供可靠依据。

Objective To explore the action of interleukin-8（IL-8） in occurrence of ulcerative colitis（UC） and UC induced by large intestinal damp-heat,and correlation between IL-8 level and severity of UC induced by large intestinal damp-heat through observing the changes of IL-8 level in the patients with active UC and UC induced by large intestinal damp-heat.Methods The level of serum IL-8 was observed in 60 patients with active UC（UC group）,and among them 30 with large intestinal damp-heat syndrome（damp-heat group） and 30 without（non-damp-heat group）,and in 16 health subjects（health group）.The patients with UC induced by large intestinal damp-heat were divided into mild group and moderate-severe group according to the severity of UC.The level of IL-8 was compared be tween UC group and health group.among damp-heat group,non-damp-heat group and health group,and between mild group and moderate-severe group.Results The level of IL-8 was higher in UC group than that in health group（P0.05）,and significantly higher in damp-heat group than that in non-damp-heat group（P0.01） and health group（P0.01）,and slightly higher in non-damp-heat group than that in health group（P0.05）.The level of IL-8 was significantly higher in moderate-severe group than that in mild group（P0.05）.Conclusion IL-8 plays an important role in the occurrence of UC and UC induced by large intestinal damp-heat and it is correlated to the severity of UC induced by large intestinal damp-heat,which can be taken as reliable basis for diagnosis of active UC and syndrome differentiation and treatment of UC induced by large intestinal damp-heat.