呫吨酮类衍生物抗肿瘤活性研究进展

Research Advances in Antitumor Activities of Xanthone Derivatives

呫吨酮是含氧杂环化合物的重要组成部分。此类化合物的生物活性与其三环骨架和骨架上取代基团的性质和位置有关。该文总结了一系列天然与合成的呫吨酮类衍生物的抗肿瘤活性,并且阐述了部分重要的抗肿瘤机制,详细介绍了一些呫吨酮类衍生物的抗肿瘤及其对靶点的作用,尤其是对蛋白激酶C调变作用的研究;还列举了部分具有癌症治疗效果的呫吨酮类化合物,包括DMXAA、普梭草素、芒果苷、降阿赛里奥、曼果斯廷等。

Xanthones （9H-xanthen-9-ones） are important components of oxygenated heterocycles. The biological activities of this kind of compounds are associated with their tricyclic scaffold and the property and position of substituents in scaffold. This paper re- viewed the antitumor activity in series of natural and synthetic xanthone derivatives,with an emphasis on some significant studies on in- teraction mechanisms. The antitumor activity of some xanthones as well as the related targets, particularly PKC modulation studies, were also discussed in detail. Partial xanthone compounds possessing effects of cancer treatment were listed such as DMXAA,psorospermin, mangiferin, norathyriol and mangostins.