血清中CaN和PTHrP测定在肺癌骨转移诊断和疗效判定中的意义

Significance of serum CaN and PTHrP in lung cancer with bone metastases

目的:探讨血清中钙调神经磷酸酶(calcineurin,CaN)和甲状旁腺激素相关蛋白(parathyroid hormone-related protein,PTHrP)的测定对肺癌骨转移患者的诊断及临床疗效评价的意义。方法:应用ELISA法检测患者血清CaN和PTHrP浓度,并比较其浓度在肺癌骨转移未治疗患者,非骨转移患者及骨转移治疗患者中的差异。结果:骨转移未治疗组患者血清CaN和PTHrP水平均明显高于非骨转移组(P<0.01),并高于骨转移治疗组(P<0.01)。结论:血清CaN和PTHrP的测定对肺癌患者骨转移的诊断及疗效评价可能具有重要意义。

Objective：To explore the clinical significance of serum Calcineurin and serum parathyroid hormone-related protein in diagnosing bone metastases of lung carcinoma and the treatment in bone metastasis of lung carcinoma.Methods：ELISA was used to detect the levels of serum CaN and PTHrP in 3 groups of lung cancer patients,without bone metastasis,before and after treatment with bone metastasis.Results：The levels of serum CaN and PTHrP in patients with bone metastases untreated were significantly increased compared with patients without bone metastases（P0.01,and the levels of serum CaN and PTHrP in patients with bone metastases untreated were significantly higher than patients with bone metastases treated（P0.01）.Conclusion：The detection of serum CaN and PTHrP may be important in diagnosing bone metastasis and evaluating the effectiveness of treatment in bone metastasis of lung carcinoma.