胃癌中HER-2和GST-π的表达及意义

Expressions and significance of HER-2 and GST-π in human gastric carcinoma

目的:探讨胃癌组织中人表皮生长因子受体-2(HER-2)和胎盘型谷胱甘肽-S-转移酶-π(GST-π)的表达及与临床病理特征的关系。方法:应用免疫组化Envision二步法,检测70例胃癌组织中HER-2和GST-π的表达情况,并结合其临床病理特点进行分析。结果:HER-2和GST-π在胃癌组织中的表达阳性率分别为27.1%(19/70)和58.6%(41/70)。阳性表达与肿瘤分化程度,侵袭深度,有无淋巴结转移及TNM分期有关(P<0.01,P<0.05),而与患者的性别及年龄、肿瘤部位和大小无关(P>0.05)。HER-2和GST-π两者之间在胃癌组织中的表达呈正相关(P<0.01)。结论:HER-2和GST-π的表达参与胃癌的生长、侵袭和转移过程。其联合检测有助于胃癌患者靶向药物和化疗药物的选择,也为胃癌的预后判断提供客观的参考指标。

Objective：To investigate the expressions of HER-2 and GST-πin human gastric carcinoma and to study the relationship with the clinicopathologic factors of gastric carcinoma.Methods： The Envision immunohistochemical stain method was used to detect HER-2 and GST-πprotein expressions in 70 sample of gastric carcinoma tissues.And their corresponding clinical data were analyzed retrospectively.Results： The positive expression rates of them were 27.1%（19/70） and 58.6%（41/70）.The positive expression rates were closely related to the differentiation of the cancer,invasion depth,lymphatic metastasis and TNM（P0.01,P0.05）,but not to the patient＇ s sex,age,tumor site and size（P0.05）.There was a positive correlation between HER-2 and GST-π expressions in gastric cancer tissues.Conclusion： HER-2 and GST-π expressions participate in the development,invasion and metastasis process of gastric cancer.Combined detection of them can be looked as an important symbol for guiding the molecular targeting therapy and chemotherapy of gastric cancer,and judging the prognosis of gastric cancer.