血清PSA、FPSA/TPSA与ACP联合检测对前列腺癌诊断的意义

Clinical significance of combined detection of serum PSA,free-to-total PSA and ACP in diagnosis of prostate carcinoma

目的:探讨血清PSA、FPSA、FPSA/TPSA与ACP联合检测在前列腺癌诊断中的临床意义。方法:用化学发光法检测前列腺癌(PC)与良性前列腺增生(BPH)患者血清中的PSA和FPSA,计算FPSA/TPSA比值;用速率法检测前列腺疾病患者血清中的酸性磷酸酶(ACP)含量,并与正常人群进行比较。结果:PC组血清PSA、FPSA和ACP水平显著高于BPH组和对照组(P<0.01),BPH组又显著高于对照组(P<0.01);PC组FPSA/TPSA比值显著低于BPH组和对照组(P<0.01)。结论:联合检测PSA、FPSA、FPSA/TPSA与ACP可有效地提高诊断PC的特异性和灵敏度;血清ACP检测可用于PC转移患者的诊断和术后监测。

Objective：To evaluate the clinical significance of combined detection of serum prostate specific antigen（PSA）,free-to-total PSA ratio（F/T） and ACP in diagnosis of prostate carcinoma.Methods： Serum PSA and FPSA were tested in patients with prostate carcinoma（PC） and patients with benign prostate hyperplasia（BPH） with the mothod of chemiluminescence immunoassay（CLIA） to calculate the ratio of FPSA and TPSA;the value of ACP was detected by Hatachi 7600-110 automatic biochemical analyzer.A group of healthy people was choosen as healthy controls.Results were compared between the three groups.Results： The mean serum level of PSA,FPSA and ACP were significantly higher in patients with prostate carcinoma than those in BPH patients and in healthy controls（P0.01）,and the mean serum level of PSA,FPSA and ACP were significantly higher in BPH patients than those in healthy controls（P0.01）,but the mean serum level of F/T was significantly lower in patients with prostate carcinoma than those in BPH patients and in healthy controls（P0.01）.Conclusion： The comdbined detection of serum PSA,FPSA,free-to-total PSA and ACP can increase the specificity and sensibility of diagnosis of prostate carcinoma effectively;Serum ACP can be used in diagnosis and monitoring after operation of patients with matastatic carcinoma of prostate.