雌、孕激素受体在宫颈癌及癌前病变中的表达及相关性研究

correlation and expression of ER,PR in cervical cancer and precancerous lesion

目的:探讨雌激素受体(ER)、孕激素受体(PR)在不同程度的宫颈鳞状上皮病变中的表达及临床病理意义。方法:采用SP免疫组织化学染色法观察ER、PR在正常宫颈、宫颈上皮内瘤变(CIN)及宫颈癌中的表达情况。结果:ER在正常宫颈组中表达率为100%,随着病变程度的增加,其表达率及表达强度逐渐降低,在宫颈癌组仅为9.76%,各组间的差异具有显著的统计学意义(P<0.01)。PR在正常宫颈组织中的表达率不如ER的表达率高,为39.29%,随着病变程度的增加,其表达率也呈降低的趋势,在宫颈癌组其表达率已降至0,各组间的差异具有显著的统计学意义(P<0.01)。结论:ER、PR的表达与宫颈癌及癌前病变发生发展的关系密切,呈一定的负相关性。ER及PR的表达下调或缺失可能是导致宫颈癌发生的重要机制之一。

Objective：To explore the expression of ER,PR in the cervical cancer and its clinicopathologic significance.Methods： SP immunihistochemistry was used to detect the expression of ER,PR in normal cervical tissues,cervical intraepithelial neoplasm（CIN） and cervical cancers.Results： The positive rate of ER was 100% in the normal cervical tissue,its positive rate and staining intensity decreased with the severity of disease,only 9.76% in cervical cancer.There was significant difference（P0.01） between different groups.The positive rate of PR was lower than ER＇s,only 39.29% in the normal cervical tissue,its positive rate decreased with the severity of disease,0 in cervical cancer.There was significant difference（P0.01） between different groups.Cconclusion： The positive rate of ER and PR correlate closely with the development of the invasion cervical cancer and precancerous lesions.And ER,PR are negatively correlated with cervical lesions.Expression of ER and PR in cervical cancer was lower or deficient,which may play an important role in the pathogenesis of cervical cancer.