FHIT基因与皮肤癌

Fragile histidine triad gene and skin cancer

FHIT基因是组氨酸三联体基因家族的成员,在嘌呤代谢中参与编码一个AP3A水解酶。该基因在3号染色体上包含常见的脆性部位FRA3B,并且致癌物质引起的损伤可以导致染色体易位从而致使基因的转录本异常。事实上,这种基因的异常转录本在所有的食管、胃和结肠癌中发现大约有一半出现异常。研究显示FHIT基因可能通过调控细胞周期,诱导细胞凋亡发挥抑制肿瘤的作用。其失活机制主要表现为启动子区域CPG岛甲基化、缺失及异常转录。同时有研究表明FHIT基因与皮肤癌的发生、发展、转移和预后有着密切的关系。本文就FHIT基因与皮肤癌关系研究最新进展做出综述。

FHIT gene,a member of the histidine triad gene family,encodes a diadenosine AP3A.The gene encompasses the common fragile site FRA3B on chromosome 3,where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene.In fact,aberrant transcripts from this gene have been found in about half of all esophageal,stomach,colon carcinomas.FHIT gene may control the cell cycle,apoptosis induced by tumor play a role in the mechanism of its inactivation is mainly expressed in the promoter region of CPG island methylation,deletion and abnormal transcription.Some studies have shown that the FHIT gene is closely related with the occurrence,development,metastasis and prognosis of the skin cancer.This article is based on the latest progress in relationship between the FHIT gene and skin cancer to make review.