通经活利汤治疗膝关节滑膜炎的临床研究

Clinical study on the curative effect and safety of TONGJING HUOLI decoction in knee synovitis

目的:观察通经活利汤治疗膝关节滑膜炎的临床疗效和安全性。方法:采用随机数字表将符合要求的220例膝关节滑膜炎患者随机分为2组,实验组120例,对照组100例。实验组患者采用通经活利汤治疗,对照组患者口服萘丁美酮胶囊,治疗28 d后按照自拟的症状体征分级量化评分表对2组患者进行疗效评定,同时观察记录2组患者治疗期间发生胃肠道反应的情况。结果:①临床疗效。实验组临床疗效优于对照组(Z=-8.992,P=0.000)。②安全性。在治疗期间实验组1例出现胃肠道反应,对照组16例出现胃肠道反应,实验组不良反应发生率低于对照组(χ2=17.597,P=0.000)。结论:通经活利汤能明显减轻膝关节滑膜炎患者膝的临床症状,改善膝关节功能,其疗效优于萘丁美酮胶囊,而且不良反应也较非甾体类抗炎药少。

Objective：To observe the curative effect and safety of TONGJING HUOLI decoction in knee synovitis.Methods：Two hundred and twenty patients with knee synovitis were randomly divided into 2 groups,120 cases in the experimental group,while the others in the control group.Patients in the experimental group were administrated with TONGJING HUOLI decoction,while the others in the control group were administrated with Nabumetone capsules.After 28 days treatment,the curative effects were evaluated according to the self-designed scoring scale of signs and symptoms.Meantime,the gastrointestinal reactions of patients occurred during the treatment period were observed and recorded.Results：The clinical curative effect of experimental group was better than that of control group（Z=-8.992,P=0.000）.During the treatment period,1 case with gastrointestinal reaction was found in experimental group,while 16 cases with gastrointestinal reactions were found in control group.Incidence of adverse reactions of experimental group was lower than that of control group（χ2=17.597,P=0.000）.Conclusion：TONGJING HUOLI decoction can significantly relieve knee clinical symptoms for the patients with knee synovitis and enhance knee function.Furthermore,its curative effect is better than that of Nabumetone capsules,and its adverse reactions are less than that of non-steroidal anti-inflammatory drugs.