丁苯酞联合依达拉奉治疗急性脑梗死的临床研究

Clinical study on dl-3n-butylphthalide combined with edaravone in treatment of acute cerebral infarction

目的观察丁苯酞注射液联合依达拉奉治疗急性脑梗死的临床疗效。方法将160例急性脑梗死患者随机分为A、B、C、D 4组,各40例,均常规使用脱水剂、降压药、调血脂药及神经营养药物。在此基础上B组加用丁苯酞注射液,C组予依达拉奉静脉滴注,D组在B组治疗的基础上加用依达拉奉。14 d为1疗程,4组患者均分别于治疗前、用药后第14天进行临床神经功能缺损程度(CSS)评分与日常生活活动能力量表(BI)评分。结果 B、C、D组显效率均显著高于A组,差异有统计学意义(P<0.01),用药后神经功能缺损程度(CSS)评分均显著低于治疗前及A组,D组用药后评分低于B、C组。结论丁苯酞注射液联合依达拉奉对急性脑梗死有协同治疗效果。

[Objective]To observe the clinical effect of dl-3n-butylphthalide injection combined with edaravone in treatment of acute cerebral infarction.[Methods]160 patients with acute cerebral infarction were randomly divided into group A,B,C and D,40 cases in each group,and all patients were treated with dehydrating agent,antihypertensive drug,lipid regulating agent and neurotrophic drug.On the basis of routine treatment,group B was given dl-3n-butylphthalide injection,group C was given edaravone by intravenous drip,and group D was given dl-3n-butylphthalide and edaravone.A course of treatment was 14 days.The scores of China stroke scale（CSS） and Barthel Index were evaluated before treatment and 14 days after medication.[Results]The obvious effective rate of group B,C and D was significantly higher than that of group A（P0.01）.The CSS score after medication of group B,C and D was significantly lower than that before treatment and group A,and score after medication of group D was lower than that of group B and C.[Conclusion]The dl-3n-butylphthalide injection combined with edaravone has synergistic effect in treatment of acute cerebral infarction.