抗生素类药物在儿科门诊使用情况分析

Usage analysis of antibiotics in the pediatric outpatient

目的调查儿科门诊中抗生素使用情况,为门诊抗生素的使用提出指导。方法根据处方管理办法和相关抗生素使用办法,结合儿科门诊的特殊性,对儿科门诊抗生素的使用进行严格管理。随机抽取2009年10月～2011年10月我院儿科门诊处方17 658张为观察组,并回顾性分析自2007年10月～2009年9月随机抽取的15 248例儿科门诊处方为对照组,对抗生素用药的情况进行统计和分析。结果①抗生素使用率:对照组(66.20%)明显高于观察组(46.20%),差异具有高度统计学意义(P<0.01)。②联合用药情况:观察组抗生素二联使用率、三联及以上使用率均低于对照组,差异具有统计学意义(P<0.05)。③二联用药具体药物联合情况以β-内酰胺类联用大环内酯类和β-内酰胺类联用林可霉素为主,对照组显著优于观察组(P<0.05)。结论我院儿科抗生素使用情况有所好转,但是仍存在使用率过高,联合用药偏高等不合理用药情况,应继续给予重视。

Objective To investigate the usage of antibiotic pediatric clinic, and give guidance to the pediatric outpatient. Methods Randomly selected 17 658 pediatric outpatient prescription from October 2009 to October 2011 in our hospital as observation group,and retrospectively selected 15 248 cases of pediatric outpatient prescriptions from October 2007 to September 2009 as the control group,compared the usage of antibiotics in the pediatric outpatient. Results ①Antibiotic usage rate was 66.20% in control group was higher than the observation group （46.20%）,the difference was statistically significant（P 〈 0.01 ）.②Combination therapy：two drugs combined usage rate, three drugs combined usage rate of observation group were less than control group. ③13-1actam combined with macrolide and β-lactam combined with lincomycin were the majority of two kinds of antibiotics joint. Conclusion In recent years, the usage rate of antibiotic pediatric clinic has improved ,but the there still has the too high utilization ,combination therapy and the relatively high irrational drug use rate,we should continue to give attention.