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齐拉西酮与利培酮对精神分裂症患者内分泌代谢的影响 被引量:2

Effect of ziprasidone and risperidone on endocrinology and metabolism in schizophrenic patients
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摘要 目的探讨国产齐拉西酮与利培酮对精神分裂症患者内分泌代谢的影响。方法将156例精神分裂症患者随机分为研究组和对照组各78例。研究组给予齐拉西酮治疗,对照组给予利培酮治疗。分别于基线、治疗4周末和8周末检测血清泌乳素、空腹血糖及血脂水平。结果与基线相比,治疗4周末和8周末研究组血清泌乳素差异无统计学意义(P>0.05),而对照组则明显升高(P<0.05);治疗4周末和8周末两组比较差异无统计学意义(P<0.05)。治疗4周末和8周末两组空腹血糖、胆固醇及甘油三酯水平与基线相比以及两组间同期相比,差异均无统计学意义(P>0.05)。结论齐拉西酮对精神分裂症患者血清泌乳素、空腹血糖以及血脂水平均无明显影响。 Objective To investigate the effect of ziprasidone and risperidone on endocrinology and metabolism in schizophrenic patients. Methods A total of 33 patients with schizophrenia were randomly divided into study group (n = 78) and control group (n = 78). Patients in the study group were given ziprasidone, while patients in the control group were given risperidone. Serum prolactin, fasting glucose, cholesterol and triglyceride levels were compared at baseline, 4-week and 8-week after treatment, respectively. Results Compared with those at baseline, serum prolactin level at 4-week and 8-week in the study group showed no significant difference (P 〉 0.05), while the level of the control group was signifi cantly increased (P 〈 0.05); serum prolactin leves at 4-week and 8-week after treatment between two groups were also statistically significant (P 〈 0.05). Compared with baseline, fasting blood glucose, cholesterol and triglyceride levels in the two groups showed no significant difference, and also there were no difference between the two groups (P 〉 0.05). Conclusion Ziprasidone has no effects on prolactin, fasting glucose and lipid levels of patients with schizophrenia.
出处 《中国现代医生》 2012年第13期58-59,共2页 China Modern Doctor
关键词 精神分裂症 齐拉西酮 利培酮 泌乳素 空腹血糖 脂代谢 Schizophrenia Ziprasidone Risperidone Prolactin Fasting blood glucose Lipid metabolism
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