腹壁下动脉插管与静脉化疗治疗中晚期宫颈癌的临床疗效

The clinical efficacy of the inferior epigastric artery catheterization and intravenous chemotherapy in the treatment of advanced cervical cancer

目的探讨腹壁下动脉插管联合静脉化疗治疗晚期宫颈癌的临床疗效。方法将72例晚期宫颈癌患者随机分为观察组和对照组,观察组采用紫杉醇静脉输注联合顺铂、5-氟尿嘧啶腹壁下动脉插管注入化疗,对照组单纯采用动脉注入化疗,第2个疗程结束时比较两组临床症状的改善情况及临床疗效,比较两组治疗的总有效率。结果第2个疗程结束后,两组症状均显著缓解,观察组总有效率为94.5%,对照组总有效率为77.1%,差异有统计学意义(P<0.05)。但两组副反应无明显差异。结论紫杉醇静脉输注联合顺铂、5-氟尿嘧啶腹壁下动脉插管注入化疗对晚期宫颈癌的疗效较单纯动脉注入化疗更优。

Objective To investigate the clinical efficacy of the inferior epigastric artery catheterization combined with intravenous chemotherapy in advanced cervical cancer. Methods A total of 72 patients with advanced cervical cancer patients were randomly divided into observation group and control group, the observation group was treated by paclitaxel infusion in combination with cisplatin, 5-fluorouracil inferior epigastric arterial injection chemotherapy, while the control group was treated with artery infusion chemotherapy, at the end of the second course of treatment the improvement of clinical symptoms, the clinical efficacy and the total efficiency were compared between two groups. Results After the end of the second courses, the symptoms between two groups were significantly alleviated, the total effective rate of observation group was 94.5%, while the total effective rate of the control group was 77.1%, there was significant difference between two groups （P 〈 0.05）. But side effects of the two groups had no significant difference. Conclusion The clinical efficacy of the inferior epigastric artery catheterization combined with intravenous chemotherapy in advanced cervical cancer is better than a simple artery infusion chemotherapy.