阿维A与其他药物治疗脓疱型银屑病疗效对比分析

Comparative analysis on clinical efficacy of acitretin and other drugs in treatment of pustular psoriasis

目的评价阿维A、甲氨蝶呤、复方甘草酸苷注射液治疗脓疱型银屑病的疗效差异。方法将156例患者随机分成3组,A组75例患者口服阿维A胶囊10 mg,每日3次;B组45例患者口服甲氨蝶呤2.5 mg,每日1次;C组36例患者用复方甘草酸苷注射液20 ml加入5%葡萄糖溶液250 ml静脉滴注,每日1次。3组疗程均为8周。结果 A、B、C 3组有效率分别为88.00%、75.56%、66.67%。3种药物治疗脓疱型银屑病的有效率比较,差异有统计学意义(P<0.01);不良反应发生率分别为37.33%、64.44%和8.33%,3种药物不良反应发生率比较,差异有统计学意义(P<0.01);追踪随访治愈患者3个月,A、B、C 3组复发率分别为7.69%、47.62%和10.00%,3种药物治疗脓疱型银屑病的复发率比较差异有统计学意义(P<0.01)。结论阿维A能更有效地控制脓疱型银屑病的症状,疗效明显,复发率低,值得在临床推广使用。

Objective To assess the efficacy of acitretin,methotrexate,Compound Glycyrrhizin for Injection in the treatment of pustular psoriasis.Methods A total of 156 patients with pustular psoriasis were enrolled and randomly divided into three groups as the group A,B and C.75 cases in the group A received acitretin 10 mg three times daily for 8 weeks,45 cases in the group B received methotrexate 2.5mg once daily for 8 weeks,while 36 cases in the group C were intravenously infused with Compound Glycyrrhizin for Iinjection 20 ml＋5% glucose 250 ml once daily for 8 weeks.Results The effective rate was 88.00% in the group A,75.56% in the group B and 66.67% in the group C,showing statistical difference among 3 groups（P0.01）.The incidence of adverse reactions was 37.33%,64.44% and 8.33%,respectively.The difference in adverse drug reactions among three groups had statistical significance（P0.01）.In 3-month follow-up for cured cases,the relapse rate was 7.69% in the group A,47.62% in the group B and 10.0% in the group C with statistical difference among 3 groups（P0.01）.Conclusion Acitretin can effectively control the symptoms of pustular psoriasis with better effects and low relapse rate,which is worthy of being clinially popularized.