Th1/Th2细胞在口腔扁平苔藓发病中的研究

The role of Th1/Th2 cell in the pathogenesis of oral lichen planus

目的探讨Th1、Th2细胞在口腔扁平苔藓(oral lichen planus,OLP)发病中的作用。方法运用免疫组织化学SABC法检测30例(糜烂型与非糜烂型各15例)OLP、10例正常口腔黏膜中Th1、Th2细胞数量及分布情况。结果 OLP组Th1、Th2数量显著高于对照组(P<0.05),Th1/Th2的比值较对照组升高,差异具有统计学意义(P<0.05),糜烂型OLP中Th1,Th2的数量及比值略高于非糜烂型,二者差异无统计学意义(P>0.05)。结论 Th1、Th2细胞在OLP的发生、发展中起重要作用。Th1细胞主要分布在淋巴浸润带紧邻上皮基底膜的位置,提示Th1细胞与基底紊乱、基底细胞液化变性有关。

Objective To discuss the role of Th1,Th2 cells in the pathological mechanism of OLP.Methods 30 OLP cases（15 erosive and 15 non-erosive） were regarded as experimental group,and 10 normal person as control group.Immunohistochemical technique was employed to study the expression of Th1,Th2 in oral mucosa.Results The expression rates of Th1 and Th2 cells in the OLP group were significantly higher than those in the NOM group（P〈0.05）.The rates of Th1/ Th2 were higher than those in the NOM group.The differences were significant（P〈0.05）.The amount of Th1,Th2 cells in the erosive OLP was slighly higher than that in the non-erosive group.The differences were not significant（P〉0.05）.Conclusions Th1,Th2 cells play an important role in the pathogenesis and development of OLP.The Th1 cells distribute near the basal cell membrane,suggesting that the Th1 cells are related with basal membrane disorder and basal cell liquefaction degeneration.