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MicroRNAs研究进展 被引量：1

Advances in MicroRNAs Research
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摘要 MicroRNAs简称miRNAs(微小RNAs),是真核生物、原核生物以及病毒中由非编码蛋白基因转录成的初级前体microRNAs加工成的调控因子.在转录后水平和蛋白质翻译水平,microRNAs通过降解或翻译抑制调控靶mRNA.这些microRNAs在广泛的生物过程中发挥重要作用,包括细胞增殖,分化和凋亡.主要介绍microR-NAs的特征,加工与成熟过程,作用机制以及其功能. MicroRNAs（miRNAs） are small regulator,noncoding RNA molecules that are transcribed as primary microRNAs （pri-microRNAs） from eukaryotic genomes,prokaryotic genomes and virus, involved in post-transcriptional and translational control of gene expression, either via degradation or translational inhibition of target mRNAs. These microRNAs play central roles in a wide range of biological processes, including cell proliferation, differentiation and apoptosis. This review has outlined the characteristics, process of maturation, mechanism of action and their function.
作者 丁伟超 陈永康 王莹
机构地区 暨南大学生命科学技术学院生物工程学系
出处 《河南师范大学学报（自然科学版）》 CAS CSCD 北大核心 2012年第2期122-126,共5页 Journal of Henan Normal University(Natural Science Edition)
关键词 MICRORNAS SIRNA 机制 功能 mieroRNAs siRNA mechanism function
分类号 Q74 [生物学—分子生物学]
  • 相关文献

参考文献35

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二级参考文献44

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共引文献5

同被引文献23

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引证文献1

河南师范大学学报（自然科学版）
2012年 第2期

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