孟鲁司特佐治毛细支气管炎41例疗效观察

Therapeutic Effect of Montelukast on 41 Cases of Bronchiolitis

目的观察孟鲁司特治疗毛细支气管炎临床疗效及对远期喘息复发的影响。方法患儿年龄6个月～2岁,随机分为两组,对照组40例,治疗组41例,两组患儿均给予相同的综合治疗,治疗组在上述常规治疗基础上加用孟鲁司特(顺尔宁)每次4 mg,每晚1次口服,观察两组病儿喘憋缓解、肺部哮鸣音消失时间及痊愈时间,并比较两组疗效,所有患儿均随访6个月,治疗组随访期间每晚继续口服4 mg顺尔宁,观察两组随访期间再次喘息发作次数。结果治疗组总有效率高于对照组,两组比较差异有统计学意义(χ2=7.204,P=0.007<0.05),治疗组在喘憋缓解、肺部哮鸣音消失时间及痊愈时间均少于对照组,两组比较差异有统计学意义,随访期间再次发生喘息情况:对照组13例,发生率13/40,治疗组例4例,发生率4/41,两组比较差异有统计学意义(χ2=5.019,P=0.025<0.05)。结论加用孟鲁司特治疗毛细支气管炎可有效缓解临床症状、缩短痊愈时间并能降低喘息再发率。

Objective To observe the clinical therapeutic effect of Montelukast on the bronchiolitis and its influence on the recurrent wheezing.Methods The 81 patients aged 6 months to 2 years old were randomly divided into two groups：40 cases for the control group,41 cases for the treatment group.Both groups received the same comprehensive treatment,while the treatment group received additional Montelukast（4 mg,p.o,q.d）.The wheezing remission time,disappearance and recovery time of wheezing in lungs of the both groups were observed,and the therapeutic effects of the two groups were compared.The follow-up was six months in both the two groups.The recurrence frequency of wheezing during follow-up period was observed.Results The total efficacy rate of the treatment group was higher than that of the control group,and the comparative difference of the two groups was statistically significant（χ2=7.204,P=0.0070.05）.As the wheezing remission time,the disappearance and recovery time of wheezing in lungs in the treatment group were all less than those of the control group,the comparative difference of the two groups was statistically significant.The wheezing reoccurred during the follow-up period.There were 13 cases in the control group（13/40）,but only 4 cases in the treatment group（4/41）.The comparative difference of the two groups was statistically significant（χ2=5.019,P=0.0250.05）.Conclusion The additional singulair based on the comprehensive treatment can effectively relieve the clinical symptoms of the bronchiolitis,shorten its recovery time and reduce the recurrence rate of wheezing.