复方甘草酸苷片联合窄谱UVB治疗掌跖脓疱病疗效观察

Observation on the effect of compound glycyrrhizin tablet combined with narrow spectrum ultraviolet B in treating palmoplantar pustulosis

目的探讨复方甘草酸苷片(美能)联合窄谱中波紫外线(NB-UVB)治疗掌跖脓疱病的临床疗效。方法将66例患者随机分成3组,各22例,治疗组:口服复方甘草酸苷片联合窄谱UVB照射;对照1组:仅口服复方甘草酸苷片;对照2组:窄谱UVB照射,3组均4周为1个疗程,分别于治疗前及治疗后第4周和第8周后观察疗效。结果治疗组、对照1组和对照2组第4周末的治愈率分别为40.91%、18.18%、13.64%,有效率分别为72.73%、40.91%、36.36%,第8周末的治愈率分别为72.73%、31.82%、22.73%,有效率分别为90.91%、63.64%、54.55%,治疗组分别与对照1组和对照2组比较,治疗后4和8周末的疗效和有效率差异均有统计学意义。结论复方甘草酸苷片联合窄谱UVB治疗掌跖脓疱病安全、有效。

Objective To explore the clinical effect of compound glycyrrhizin tablets combined narrow spectrum ultraviolet B in the treatment of palmoplantar pustulosis. Methods Sixty-six patients were randomly divided into 3 groups （n = 22 in each group） ： treatment group was treated with compound glycyrrhizin tablets and narrow spectrum ultraviolet B and control 1 group was treated with compound glycyrrhizin tablets and control 2 group narrow spectrum ultraviolet B. Four weeks was consisted as one treatment course and examination was made before treatment, at the fouth weekend and eighth weekend after treatment respectively. Results After 4 weeks, the cure rate of treatment group, control 1 group and control 2 group were 40.91% ,15. l g% and 13.64% respectively, and the total effective rate of the three groups were 72. 73% ,40. 91% and 36. 36% respectively, After 8 weeks,the cure rate of treatment group, control 1 group and control 2 group were 72. 73% ,31.82% and 22. 73% respectively, and the total effective rate of the three groups were 90. 91% ,63.64% and 54.55% respectively. Treatment group had higher cure rates and total effective rates compared with that of group control 1 and 2 at the 4 weeks and 8 weeks treatment with significant difference（all P 〈 0. 05）. Conclusion Compound glycyrrhizin tablets combined with narrow spectrum ultraviolet B were safe and effective in the treatment of palmoplantar pnstulosis.