脂蛋白(a)与冠心病相关性探讨

Discussion on correlation between lipoprotein(a) and colonary heart disease

目的探讨脂蛋白(a)(Lp-a)在冠心病发生和发展中的作用。方法同期测定34例急性心肌梗死(AMI)、123例非心肌梗死冠心病和163例非冠心病病人血清Lp-a浓度。结果 AMI组、非心肌梗死冠心病组、非冠心病组血清Lp-a浓度分别为(51.17±41.99)mg/dl、(28.90±29.61)mg/dl、(12.54±8.50)mg/dl,三组差异有统计学意义(P<0.01)。非心肌梗死冠心病组中,局限性狭窄亚组、弥漫性狭窄亚组血清Lp-a浓度分别为(22.84±3.73)mg/dl、(33.33±3.66)mg/dl,轻度狭窄亚组、中度狭窄以上亚组Lp-a水平分别为(22.04±3.25)mg/dl、(31.74±3.49)mg/dl,每两组间差异均有统计学意义(P<0.05)。结论血清Lp-a浓度升高可能促进冠心病的发生和发展,随冠状动脉病变程度加重而依次升高,是冠心病的危险因素。

Objective To study the effect of lipopmtein（a） （Lp-a） in the occunence and development of coronary heart disease. Methods The serum Lp-a concentration in 34 cases of myocardial infarction （ AMI）, 123 cases of non myocardial infarction coronary heart disease and 163 cases of non coronary heart disease were determined. Results Serum Lp-a concentration was （51.17± 41.99） mg/dl, （28.90 ± 29. 51 ） mg/dl, （ 12.54 ±8.50） mg/dl in AMI group, non myocardial infarction coronary heart disease group and non coronary heart disease group respectively. There were statistical significant difference among the 3 groups （P 〈 0.01 ）. In non coronary heart disease group, they were （22. 84 ±3.73） mg/dl and （33.33 ±3.66） mg/dl in local narrow subgroup and diffuse narrow subgroup respectively. And （22.04 ± 3.25 ） mg,/dl and （31.74 ±3.49 ） mg/dl in mild narrow subgroup and moderate or more narrow subgroup. There were statistical significant difference between every two groups. Conclusion The increase of serum Lp-a concentration may promote the occurrence and development of coronary heart disease. The Lp-a concentration gradually increase with the increase of coronary artery pathological changes, and its increase may be a risk factor for coronary heart disease.