艾滋病毒感染者和艾滋病患者外周血T淋巴细胞亚群与中医证型的相关性研究

Research of Relationship Between HIV/AIDS Syndrome Differentiation Type of TCM and CD45RO^+、CD45RA^+T Lymphocyte Subsets

目的:探索艾滋病毒感染者和艾滋病患者(HIV/AIDS)中医证型与外周血CD45RO+、CD45RA+T淋巴细胞亚群的关系。方法:选择HIV/AIDS 276例,健康对照者11例,均进行外周血CD45RO+、CD45RA+T淋巴细胞亚群检测并对HIV/AIDS进行中医辨证分型。结果:HIV/AIDS各证型与健康人相比,在CD4/CD45RA+、CD4/CD45RO+方面多表现为显著性下降(P<0.05);各证型间比较,气血亏虚、气血亏虚兼血瘀组CD4/CD45RO高于痰湿内蕴组,气血亏虚、脾肾两虚组高于阴虚火旺组(P<0.05)。结论:在HIV感染所致的免疫损害中,反映机体免疫功能改变的CD45RO+、CD45RA+T淋胞亚群能在一定程度上反映HIV/AIDS中医证型及病程演变,表现出由虚证-虚实夹杂证-实证之间免疫损害逐渐加深的趋势。

Objective：To explore the relationship between HIV/AIDS TCM syndrome differentiation type（TCM-SDT） and CD45RO＋、CD45RA＋T cell subsets.Methods：276 cases of HIV/AIDS patients,11 cases of healthy controls,detecting peripheral blood CD45RO＋、CD45RA＋T lymphocyte subsets and HIV/AIDS TCM-SDT.Result：compared to healthy people,HIV/AIDS patients significantly decreased in CD4/CD45RA,CD4/CD45RO;Comparison among different TCM-SDT,Qi-Xue deficiency syndrome and Qi-Xue deficiency and blood stasis syndrome are higher than Phlegm-dampness accumulation syndrome in CD4/CD45RO,Qi-blood deficiency syndrome and Asthenia of both the Spleen and Kidney syndrome are higher than Yin deficiency and Heat exuberance syndrome（P0.05）.Conclusion：HIV/AIDS TCM-SDT is related with CD45RO＋,CD45RA＋T cell subsets,showed the trend of gradually deepening on immune damage from asthenia syndrome to sthenia syndrome.