强迫症患者的错误监测与注意网络功能研究

A study of error monitoring and attention networks in the patients with obsessive-compulsive disorder

目的探讨强迫症（OCD）患者错误监测功能和注意网络功能。方法对确诊的33例OCD患者进行错误监测任务和注意网络测定（ANT），并与31名正常组的实验结果相比较。结果OCD组和正常组在错误监测任务中全对（FC）、全错（FE）、不确定、脱失数目[FC（121．03±4．41）个／（135．61±3．28）个、FE（19．30±3．69）个／（9．45±2．33）个、不确定数（8．27±2．16）个／（2．87±0．70）个、脱失数目（13．70±2．60）个／（4．26±1．24）个]差异有统计学意义（P〈0．05）。在注意网络功能测验中，OCD组与正常组在注意的警觉网络的反应时（RT）差异具有统计学意义（P〈0．05）；错误监测功能与注意网络功能有着相关性。结论OCD患者存在错误监测功能和注意网络功能的损害，其主要原因可能是由于前扣带回皮层结构和功能的异常所致。

Objective To investigate the error monitoring and attention network in patients with obsess- ive-eompulsive disorder （OCD）. Methods 33 OCD patients and 31 healthy subjects were tested with the error monitoring task and attention network test. Results There were significant differences between the patients with OCD and heath controls on Full Correct （FC） , Full Error（ FE ） , the numbers of uncertain, the nmnbers of dropout in the error monitoring task （ FC （ 121.03± 4.41 ） / （ 135.61 ± 3.28 ） , FE （ 19.30 ±3.69 ） / （ 9.45 ± 2.33 ） , the num- bers of uncertain （ 8.27± 2.16 ） / （ 2.87 ± 0.70 ）, the numbers of dropout （ 13.70 ±2.60 ） / （ 4.26 ± 1.24 ） ） （P 〈 0. 05 ）. In the attention network test,the comparison between the patients with OCD and healthy subjects on the RT of the alerting network was significant differences （P〈 0.05 ）. There was a significant correlation between attention network and error monitoring. Conclusion The impairment of the error monitoring as well as attention network in patients with OCD may be involved in the dysfunction of anterior cingulate cortex.