隔药饼灸对乏氧肿瘤细胞及肿瘤放疗免疫系统的影响

Indirect Moxibustion on Hypoxic Tumor Cells and Immunological Function of Tumor Undergoing Radiotherapy

采用隔药饼灸结合1 37CSγ射线放疗对实体瘤 (HAC)小鼠进行研究 ,不同时间肿瘤体积及瘤重抑制率表明 ,艾灸能增强对乏氧肿瘤细胞的杀伤作用。小鼠荷瘤后NK、LAK、IL 6活性及IL 2含量均明显降低 ,放疗后除NK活性外 ,均进一步降低 ,经艾灸治疗可以明显提高NK、LAK及IL 6活性和IL 2含量 ,其中LAK活性达到正常水平。

This article studies the effect of indirect moxibustion on HAC tumor bearing mice treated with radiotherapy. The results of hypoxic tumor regeneration after irradiation showed that combination of the indirect moxibustion and radiotherapy had the coordinating efficiency of antitumor effect. The NK activity, LAK activity, IL 2 content and IL 6 activity of tumor bearing mice were all significantly depressed. All the above parameters were further depressed after irradiation except for NK activity. Indirect moxibustion could promote all the parameters in different degrees, and LAK activity reached the normal level. The results showed that indirect moxibustion's influence on IL 6 activity and IL 2 content can promote NK activity, LAK activity and recover immunological function.