支气管肺泡灌洗液中肿瘤标志物的研究

The study on the significance of tumor markers in BALF

方法 :应用放射免疫方法对 2 6例肺癌 (观察组 )和 2 0例肺良性疾病 (对照组 )患者的支气管肺泡灌洗液和血清中降钙素、β2 —微球蛋白和癌胚抗原的含量进行了测定。结果表明 :1在血清中肺癌组仅降钙素高于对照组 (P<0 .0 1) ;2在支气管肺泡灌洗液中肺癌组所有三项肿瘤标志物均比对照组明显升高 (P<0 .0 1) ;3取对照组 95 %的可信限即 x+1.96 Sx为各项指标的阳性界值 ,在支气管肺泡灌洗液中降钙素、β2 —微球蛋白和癌胚抗原对肺癌的阳性率分别为 92 .3%、80 .7%和 88.6 %。提示支气管肺泡灌洗液中肿瘤标志物的测定对早期和周围型肺癌的诊断有一定的意义 ,其临床价值优于血清。

Method The Calcitonin(CT)、β 2-microglobulin(β 2-MG) and carcinoembryonic antigen(CEA)in BALF and serum were studied for 26 cases of lung cancer(study group) and 20 cases of benign pulmonary disease(control group)by means of RIA.Results that only CT level was significantly higher in lung cancer group than in benign pulmonary disease group by the measurement of serum(P<0 01).The level of all 3 tumor markers measured in BALF were much higher in lung cancer group than in benign pulmonary disease group(P<0 01).If the confidence limit of 95 percent of the control group in BALF were designated as the positive limit for the test,the positive of CT、β 2-MG and CEA for lung cancer group in BALF were respectively 92 3%、80 7% and 88 6%.Conclusion that the measurement of tumor markers in BALF had more significant value than the measurement of tumor markers in serum for the diagnosis of early stage and peripheral type pulmonary carcinoma.