Phakellia属海绵次生代谢产物研究进展

Research progress on secondary metabolites from marine sponge of genus Phakellia

海绵是目前海洋天然产物研究中最吸引人的海洋生物之一,海绵中含有丰富的、结构新颖的次生代谢产物,大多数具有显著的生理活性。Phakellia属海绵属于寻常海绵纲软海绵目小轴海绵科,种类较多,分布广泛,在国内外得到了广泛的研究。对近几十年来从Phakellia属海绵中分离鉴定的次生代谢产物进行了系统的归纳整理,这些化学成分主要包括环肽、生物碱、聚醚、萜类、甾醇、炔酸等种类,并对其药理活性进行了简单总结,对Phakellia属海绵的进一步研究开发具有一定的借鉴和指导意义。

Marine sponge is one of the most attractive marine organism on the research of marine natural products. Sponge contains abundant new secondary metabolites, most of which have significant biological activities. Phakellia spp., belonging to Axinellidae, Halichondrida, Demospongiae, is widely distributed at home and abroad, and it has been widely studied. This paper reviews the progress in the chemical and biological activities of the secondary metabolites from the sponge of genus Phakellia spp. in the past decades. The secondary metabolites mainly include cyclic peptide, alkaloids, polyether, terpenoids, sterols, and acetylenic acids. This paper is meaningful to the further research and development of marine sponge Phakellia spp.