老年人甲状腺激素与脱氢表雄酮相关性的研究

The study of correlation between the Thyroid hormone and dehydroepiandrosterone (DHEA) in the old persons

目的 :观察增龄对人血清中甲状腺激素 (TH)及脱氢表雄酮 (DHEA )的变化以及用小剂量 TH治疗后老年人甲状腺功能及 DHEA的改变。方法 :从健康体检的人群中 ,选择 40例老年人作为治疗组 ,选择老年前期 30例及青壮年期 30例作为对照组 ,用放免法分别测定甲状腺功能及 DHEA,并检查肝功能、心电图等。治疗组每天服甲状腺干片 10 m g,连服6个月。在 3个和 6个月后重复以上检查 ,其结果与治疗前及对照组比较。结果 :血清中 TT3、 FT3、 FT4、 DHEA随增龄而逐渐降低 ,TT4改变不明显 ,老年组经小剂量 TH治疗后 ,血清 FT3、 FT4明显升高 ,六个月后 TT3、 DHEA也呈有意义的升高。以上指标均接近老年前组水平 ,结论 :增龄可使甲状腺功能及 DHEA逐渐降低 ,用小剂量的 TH治疗老年人 ,可提高血清中 TH及

Objective:To get the information about the changes of the Thyroid hormone(TH) and DHEA in the serum with aging,and the changes of the thyroid function and DHEA in the old persons treated by small dose of TH Methods:40 cases of old persons as treatment group, 30 cases of healthy presenium person and 30 cases of young robust years as control group,thyroid function and DHEA were measured by radio immunoassay Treatment group:taking thyroid tablet 10 mg per day for 6 months,and in the third and the sixth months of treatments,they were reexaminated,the sesults were compared between those of the treatment group and control group Results:TT\-3、FT\-3、FT\-4 DHEA fell gradually with aging,the changes of TT\-4 were not distinct,after treatments,FT\-3、FT\-4 obviously elevated in the old person and TT\-3、DHEA also elevated after 6 months,all the data were close to the that of presenium Conclusion:The thyroid function and DHEA decrease gradually with the aging,taking small dose of TH can improve the level of the TH and DHEA in the serum of the aged