小剂量米非司酮和去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血的临床观察

Clinical significence of mifepristone and desogestrel-ethinylestradiol in the treatment of dysfunctional uterine bleeding perimenopausal period

目的比较小剂量米非司酮和去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血的临床疗效。方法对110例围绝经期功血患者分别给予米非司酮和去氧孕烯炔雌醇治疗,对疗效进行分析比较。结果米非司酮组治疗有效率84.6%,去氧孕烯炔雌醇组治疗有效率84.4%,2组差异无统计学意义(P>0.05);2组治疗后子宫内膜明显变薄,差异均有显著意义(P<0.05)。2组不良反应均轻微。结论米非司酮和去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血的临床效果相当,长期应用米非司酮应注意其安全性。

Objective To assess the efficacy of mifepristone and desogestre-ethinylestradiol in the treatmen of dysfunctional uterine bleeding in perimenopausal period. Methods The results of mifepristone and desogestrel-ethinylestradiol treatment were analyzed in 110 patients with perimenopausal period dysfunctional uterine bleeding. Results There was no statistical difference in effective rate of mifepristone group and desogestrel-ethinylestradiol group（P0.05）.Two groups both had few adverse reactions. Conclusion Mifepristone is as effective as desogestrel-ethinylestradiol in treatment of perimenopausal-period dysfunctional uterine bleeding,and the safety of long time mifepristone treatment should be considered.