每日短时血液透析对糖尿病肾病重度浮肿患者的意义

Clinical application of short daily hemodialysis in case of diabetic nephropathy with severe edema

【目的】研究每日短时血液透析（daily hemodialysis,DHD）在糖尿病肾病重度浮肿患者中的应用。【方法】选择2006年1月-2010年6月在我科住院的32例糖尿病肾病（diabetic nephropathy,DN）合并重度浮肿患者,随机分为A、B两组,每组16例,A组采用DHD加DN常规药物治疗,每日行血液透析2.5~4 h,连续5~14 d;B组单纯应用DN常规药物治疗。观察两组尿蛋白、血浆白蛋白、肾功能、心脏指数、浮肿等情况变化。【结果】A、B两组治疗后尿蛋白均减少,血浆白蛋白上升,肾功能均得到不同程度改善。A组患者浮肿完全消退,较B组临床症状改善明显（P〈0.05）。【结论】DHD对DN合并重度浮肿患者有明显疗效。

【Objective】Objective To study the clinical application of short daily hemodialysis in case of diabetic nephropathy with severe edema.【Methods】 32 cases were divided into two groups randomly,Group A used DHD and conventional drugs,Group B received drugs only.Group A was treated by hemodialysis 2.5 to 4 hours daily,continued for 5 to 14 days.The urinary protein,plasma proteins,renal functions were observed in Group A and Group B.【Results】Both two groups after treatment of urinary protein were reduced,plasma albumin rises,renal function were improved in different degree.A group all patients with edema were dissipated,in A group than in B group,the clinical symptoms improved significantly（P 〈 0.05）.【Conclusion】 DHD has remarkable effect on diabetic nephropathy with severe edema.