降钙素基因相关肽在骨修复和骨重建中的作用研究现状

Calcitonin gene-related peptide in bone repair and bony remodeling

骨折愈合是一个极其复杂的过程,需多种因子参与调节。CGRP通过调节成骨细胞和破骨细胞功能、影响骨折局部的血液供应、诱发损伤局部炎症细胞浸润,从而参与骨折愈合的调节。骨折愈合仅仅是骨修复、骨重建中的一个方面,虽然已经认识到降钙素基因相关肽在骨修复及骨重建中的重要作用,但其具体作用机制仍不明了。

Fracture healing is an extremely complex process,need a variety of factors involved in the regulation.CGRP by regulating osteoblast and osteoclast function,the impact fracture the local blood supply,local inflammatory cell infiltration induced injury to participate in the regulation of fracture healing.Fracture healing is just bone repair,bony remodeling in one aspect,having been recognized calcitonin gene-related peptide in bone repair and bony remodeling of the important role,but its exact mechanism is still not clear.