经颈内动脉骨髓干细胞移植治疗脑梗死后遗症

TREATING CEREBRAL INFARCTION BY BONE MARROW STEM CELL TRANSPLANTATION INTERNAL CAROTID

目的:探讨骨髓干细胞移植治疗脑梗死后遗症的临床疗效与可行性。方法:病人9例,平均60.5岁。脑梗死发生后2wk～22mo。50岁以下取自体骨髓血120～150mL,50岁以上(含50岁),取胎儿脐带血约80mL。实验室即刻分离,分离后的骨髓干细胞(混于10mL生理盐水中)。经股动脉穿刺,以Seldinger氏方法,送入5.0F猎人头导管,导管尖端置于颈内动脉处缓慢注入。结果:移植术后2wk～3mo观察。肢体运动,痛温感觉语言功能。明显改善6例,改善2例,无变化1例。总有效率89%。结论:经颈内动脉骨髓干细胞移植治疗脑梗死后遗症方法近期有效,安全性目前可靠。

Objective：Discussion of clinical effects and feasibility about BMSCT by internal carotid cure CIS.Methods：The 9 case of patients with from 2 week to 22 month after cerebral infarction,from 35 to 69 years.Drawing autologous bone marrow blood 120-150mL（age〈50）.But drawing fetal umbilical cord blood 80mL（age≥50）.Total drawn blood were centrifuged immediately in laboratory,centrifuged blood（bone marrow stem cell）blend in 0.9%NS 10ml.We inserted 5.0F the hunter head catheter by Seldinger method at arteria cruralis puncture spot,Then,we placed catheter into internal carotid to slowly inject the blended bone marrow stem cell.Results：We observed limb kinetic,the feeling of pain and temperature,and speaking function in Postoperative 2 week to 3 month.There were 6 cases complete recover,there were 2 cases partial recover,and there was 1 case unrecover,in 9 cases.Total effective rate is 89%.Conclusion：The method of BMSCT by internal carotid cure Cerebral infarction sequela were safe and effective.