痛风性肾病患者血清胱抑素C和尿微量白蛋白/尿肌酐测定的临床意义

Clinical significance of Cys-C and urine microalbumin/urine creatinine determination in patients with gouty nephropathy

目的探讨痛风性肾病患者胱抑素C(Cys-C)和尿微量白蛋白、尿肌酐水平的变化及意义。方法对109例痛风患者(其中并发痛风性肾病59例,无并发症50例)和正常对照60例采用乳胶颗粒增强免疫比浊法测定血清胱抑素,同时用免疫比浊法测定尿微量白蛋白,用酶法测定尿肌酐。并计算尿微量白蛋白、尿肌酐的比值。结果痛风性肾病组血清胱抑素和尿微量白蛋白/尿肌酐平均明显高于对照组(P<0.01),痛风非肾病组与正常对照组比较无统计学差异(P>0.05)。结论血清胱抑素C和尿微量白蛋白/尿肌酐随着痛风性肾病的发生以及严重程度逐渐增高,可作为早期诊断痛风性肾病较敏感的指标,对于监测早期痛风性肾病的发生、病情发展程度有重要意义。

Objective To investigate the Changes and significance of CystatinC（Cys-C） and urine microalbumin/urine creatinine in patients with gouty nephropathy.Methods Cys-c was measured by immunoturbidimetry in 109 patients with gouty nephropathy（59 cases of concurrent gouty nephropathy,50 cases with no complications） and 60 controls.Meanwhile,urine microalbumin and urine creatinine were measured by immunoturbidimetry and enzyme method,respectively.The ratio between urine microalbumin and urine creatinine was calculated.Results Cys-C levels and urine microalbumin/urine creatinine in gouty nephropathy group were significantly higher than normal control group（P0.05）.Conclusion The gouty nephropathy occurrence and patient’s condition degree can be a sensitive indicator for the early diagnosis of gouty nephropathy and can monitor the occurrence and degree of progression of gouty nephropathy.