恶心呕吐对妊娠妇女生活质量的影响

Effect of health-related quality of life in women with nausea and vomiting of pregnancy

目的对有恶心呕吐症状的妊娠妇女生活质量进行横断面调查,分析影响生活质量的社会及躯体因素。方法 195例有恶心呕吐症状的妊娠妇女,孕6～14周,采用妊娠专用恶心呕吐量化表(PUQE)对患者症状进行量化,运用医疗结局研究量表简表SF-36及妊娠恶心呕吐生活质量量表(NVPQOL)对患者的生活质量进行评测。记录患者的人口学特征,运用多元回归分析筛选影响生活质量的社会及躯体因素。结果妊娠呕吐患者最常见的症状依次为恶心(96.4%),干呕(91.3%),呕吐(63.1%);年长及较高收入患者的症状相对比较轻。两种量表均显示,PUQE评分是影响妊娠妇女生活质量的主要因素。回归分析表明,就患者的躯体症状而言NVPQOL比SF-36更为敏感(OR分别为2.463及1.588)。结论恶心呕吐症状是引起妊娠妇女生活质量下降的主要原因,特异性量表NVPQOL用于妊娠呕吐患者生命质量的测试优于普适性量表SF-36。

Objective To investigate the quality of life in women with nausea and vomiting of pregnancy and analyze the main social and somatic factors impacting the quality of life.Methods One hundred and ninety five women with nausea and vomiting of pregnancy who attended the antenatal clinic between 6 and 14 weeks of gestation were invited to complete the pregnancy-unique quantification of emesis and nausea（PUQE） for quantitative analysis of symptoms.The quality of life was measured by SF-36 and nausea and vomiting of pregnancy quality of life questionnaire（NVPQOL）.The demographic characteristics were recorded.Logistic regression analysis was performed to sift the social and somatic factors impacting the quality of life.Results Nausea（96.4%）,retch（91.3%） and vomiting（63.1%） were the most common symptoms of women with nausea and vomiting of pregnancy,older and high-income patients’symptoms are relatively light.Both tests demonstrated that the quality of life was significantly correlated with PUQE scores,but the NVPQOL is more sensitive to physical symptoms than the SF-36（OR 2.463 versus 1.588）.Conclusion Nausea and vomiting of pregnancy are the main factors which have a profound impact on women’s quality of life.The NVPQOL in measuring the quality of life of women with nausea and vomiting of pregnancy is superior to SF-36.