Th17细胞与哮喘发病的相关性

The Correlation of the Attack of Asthma and Th17 Cells

哮喘传统上认为是以Th2型免疫应答占优势的Thl/Th2细胞功能失衡所致。近年来,大量研究证实Thl7细胞在哮喘气道炎症中发挥重要作用,使人们对哮喘有了崭新的认识。大量研究表明Thl7与Th2共同参与哮喘发病,Thl7/IL-17不仅介导哮喘中性粒细胞性气道炎症,也调节嗜酸粒细胞性炎症,与气道高反应性、气道黏液分泌和激素抵抗均密切相关。

Asthma have classically been considered as the results of dysregulation of Thl/Th2 paradigm, dominated by Th2 cells. Recently, researches demonstrate that Thl7 cells play crucial roles in the development of asthmatic inflammation, which provides new insight into the pathogenesis of asthma. A lot of researches show that Thl7 and Th2 involved in controlling asthma, Thl7/IL-17 not only mediated neutrophilic airway inflammation, but also regulated inflammation eosinophilic airway inflammation, airway hyperresponsiveness and mucin secretion, steroid resistance are closely related.