平痛新联合阿托品用于肾绞痛镇痛的效果观察

Curative effect observation on combined using of nefopam and atropine to treat renal colic

目的观察平痛新联合阿托品对肾绞痛镇痛的效果。方法对临床确诊的257例由泌尿系结石所引起急性肾绞痛患者随机分组,131例为观察组,应用平痛新联合阿托品肌注;126例为对照组,应用哌替啶联合阿托品肌注。对比观察两组止痛效果及副作用。结果观察组总有效率为90.9%,对照组总有效率为92.9%,两组比较差异无统计学意义(P>0.05)。而观察组复发率低,副作用小。结论平痛新联合阿托品对泌尿系结石所致肾绞痛镇痛效果与哌替啶联合阿托品的镇痛效果无明显差别,且复发率低,副作用少,无成瘾性。

Objective To observe the analgesic effect of combined using of nefopam and atropine on renal colic.Methods 257 confirmed patients who suffered renal colic caused by urinary stone were divided into two groups： 131 for observation group who were jointly used nefopam and atropine and 126 for control group who were jointly used pethidine and atropine.The effect of relieving pain and side effect were observed and compared between the two groups.Results The total effective rate of the observation group is 90.9% and the control group is 92.9%.The difference between two groups showed no statistical significance（P〉0.05）.However the recurrence rate and side effete of the observation group are lower than the control group.Conclusion It is no significant difference between the observation group and the control group to treat renal colic caused by urinary stone and it is worthy of using for clinic patients because of its lower recurrence rate and addiction.