泮托拉唑预防急性脑血管病并发应激性溃疡的效果观察

Effect observation of Pantoprazole in the prevention of acute cerebrovascular disease complicated with stress ulcer

目的探讨泮托拉唑对预防急性脑血管病并发应激性溃疡出血的作用。方法对两组各126例急性脑血管病例分别应用泮托拉唑和雷尼替丁预防应激性溃疡出血进行对照观察。结果泮托拉唑组中有5例出现应激性溃疡出血,发生率为3.97%。雷尼替丁组中有23例合并有应激性溃疡出血,发生率18.25%。两组比较,差异有统计学意义(P<0.05)。结论泮托拉唑比雷尼替丁更能有效地预防急性脑血管病并发应激性溃疡出血。

Objective To study the effect of Pantoprazole in preventing acute cerebrovascular disease complicated with stress ulcer bleeding.Methods The controlled study was preformed in 126 patients in each group who received Pantoprazole and Ranitidine to prevent stress ulcer bleeding respectively.Results Pantoprazole group had 5 cases of stress ulcer bleeding and the incidence rate was 3.97%.Ranitidine group had 23 cases associated with stress ulcer bleeding and the incidence rate was 18.25%.The difference between the two groups showed statistical significance（P〈0.05）.Conclusion Pantoprazole is more effective than Ranitidine in preventing acute cerebrovascular disease complicated with stress ulcer.