经肝动脉加热碘油栓塞治疗肝转移癌的疗效分析

Effect analysis of transcatheter arterial thermo-ipiodol embolization in treatment of liver metastatic carcinoma

目的评价经肝动脉加热碘油栓塞治疗肝转移癌的临床疗效。方法 126例肝转移癌患者分为两组,采用肝动脉加热碘油栓塞治疗的63例为加热组,采用常温碘油栓塞治疗的63例为常温组。并进行治疗前后肿瘤大小及肝功能等变化的对比分析。结果加热组有效率为61.90%(39/63),常温组有效率为47.62%(30/63),两组比较,差异有统计学意义(P<0.05)。两组术后肿瘤大小变化比较差异有统计学意义,肝功能变化比较差异无统计学意义。加热组6、12、18、24个月生存率分别为100%(63/63),84.13%(53/63),49.21%(31/63),25.40%(16/63);常温组分别为90.48%(57/63),63.49%(41/63),34.92%(22/63),12.70%(8/63)。同时,两组的术后恶心呕吐、肝区疼痛的发生率相比较,均有明显的统计学差异。结论经肝动脉加热碘油栓塞治疗肝转移癌的效果优于常温组的治疗,且不良反应发生率低。

Objective To evaluate the clinical effects of transcatheter arterial thermo-lipiodol embolization in treatment of liver metastatic carcinoma.Methods 126 cases of liver metastatic carcinoma patients were divided into two groups,63 cases treated with transcatheter arterial thermo-lipiodol embolization were classified as heating group;63 cases treated with transcatheter arterial normal temperature of lipiodol embolization were classified as normal group.And to analyze the tumor size and change of liver function comparative before and after the treatment.Results The effective rate of heating group and normal group was 61.90%（39/63） and 47.62%（30/63） respectively.The difference between the two groups showed statistical significance（P〈0.05）.The difference of postoperative tumor size changes between two groups showed statistical significance,but liver function changes were not.In heating group,the survival rate of 6,12,18 and 24 months were 100%（63/63）,84.13%（52/63）,49.21%（31/63） and 25.40%（16/63）,respectively;in normal group,the survival rate were 90.48%（57/63）,63.49%（42/63）,34.92%（22/63） and 12.70（8/63）,respectively.To compare the incidence of postoperative nausea and the pain of liver area of the two groups,it had statistically significant differences.Conclusion The effect of transcatheter arterial thermo-lipiodol embolization in treatment of liver metastatic carcinoma was better than the normal group,and the incidence of untoward effect was low.