MODS患者血清铜蓝蛋白测定的意义

Significance of detection of serum ceruloplasmin in diagnosis of MODS patients

目的探讨血清中铜蓝蛋白动态变化对多器官功能障碍综合症(MODS)患者早期诊断和病因判断的价值。方法于入院当天分别检测60例MODS患者(MODS组)、30例非MODS患者(对照组)血清铜蓝蛋白(CP)、超敏C反应蛋白(CRCP)、α-酸性糖蛋白(AAG)的含量,并对入选的住院患者进行APACHEⅡ和MODS评分。结果MODS组与对照组相比其APACHEⅡ、MODS评分、血清铜蓝蛋白(CP)、超敏C反应蛋白(CRCP)、α-酸性糖蛋白(AAG)的比较,差异有统计学意义(P<0.05)。非感染组与感染组相比较,铜蓝蛋白与超敏C反应蛋白均明显升高,差异有统计学意义(P<0.05)。结论 MODS患者铜蓝蛋白、超敏C反应蛋白、α-酸性糖蛋白的检测有助于MODS早期诊断;铜蓝蛋白及超敏C反应蛋白的监测有助于MODS病因的初步判断。

Objective To investigate the significance of dynamic changes of serum ceruloplasmin in multiple organ dysfunction syndrome（MODS）for early diagnosis and treatment of the cases.Methods The levels of serum ceruloplasmin（CP）,high-sensitivity C-reactive protein（CRCP）,α-acid glycoprotein（AAG in 60 MODS patients,MODS group）on the day of admission and 30 cases of non-MODS patients（control group）were determined and analyzed.The APACHE Ⅱ,MODS score were compared between two groups.Results The APACHE Ⅱ,MODS score,based on the levels of serum ceruloplasmin,high-sensitivity C-reactive protein and α-acid glycoprotein in MODS group were significantly different compared to the control group（P0.05）.Compared with non-infection group,ceruloplasmin and C-reactive protein were significantly increased,the difference was significant（P0.05）.Conclusion In MODS patients,ceruloplasmin and C-reactive protein test can help early diagnose the syndrome;ceruloplasmin and C-reactive protein monitoring also can help determine the cause of MODS useful for guiding treatment of MODS patients.