老年人冠状动脉狭窄程度与超敏C反应蛋白及脂蛋白(a)水平的研究

The Relationship Between The Severity of Coronary Artery Stenosis of The Elder and The Levels of Lipoprotein(a) and High Sensitivity C-reactive Protein

目的:探讨老年人冠脉狭窄程度与超敏C反应蛋白(hs-CRP)及脂蛋白(a()LP(a))水平的关系。方法:分析研究260例年龄>60岁的经行冠脉造影检查明确诊断冠心病的患者的冠脉狭窄程度,以及术前空腹采血测定其hs-CRP及LP(a)的水平。结果:①冠脉病变组(186例)与对照组(76例)比较,冠脉病变组Lp(a)和hs-CRP水平分别为(3.30±4.30)mg/L和(146.30±3.21)mg/L,对照组分别为(1.32±2.32)mg/L和(40.26±2.44)mg/L,二者存在差别(P<0.01),差别有统计学意义。②各个亚组病与对照组比较各亚组(单支病变组、双支病变组、三支病变组)hs-CRP和LP(a)与对照组相比较存在明显差异,单支病变组51例,双支病变组72例,三支病变组63例。单支病变组hs-CRP和Lp(a)水平分别为(2.11±1.31)mg/L和(41.58±2.32)mg/L,双支病变组分别为(2.97±2.11)mg/L和(47.12±1.21)mg/L,三支病变组分别为(3.42±2.16)mg/L和(60.13±3.54)mg/L,P<0.05,差别有统计学意义,且随着病变支数的增加,hs-CRP和LP(a)呈增高趋势。并行单因素相关分析,hs-CRP和LP(a)与冠脉病变支数有正相关关系(P<0.05)。③男性病变组(107例)和女性病变组(79例),男性组hs-CRP和LP(a)水平分别为(1.87±2.11)mg/L和(43.60±2.18)mg/L,女性病变组hs-CRP和LP(a)水平分别为(3.33±1.70)mg/L和(50.77±2.47)mg/L,二者存在差别,P>0.05,差别无统计学意义。结论:老年人冠脉狭窄程度与血清Lp(a)和hs-CRP水平变密切相关,呈正相关,老年男性冠心病患者与女性冠心病患者相比,血清Lp(a)和hs-CRP水平无显著差异。

Objective： To investigate the relationship between the severity of coronary artery stenosis of the elder and the levels of lipoprotein（a） and high sensitivity c-reactive protein.Methods：260 patients underwent coronary angiography and measured the levels of Lipoprotein（a） and high sensitive C-reactive protein,and evaluated The severity of coronary artery lesions through the number of diseased arteries.Results： ①Compared with control group,the levels of hs-CRP and LP（a） of CHD group increased evidently（P〈0.05）.②The levels of hs-CRP and LP（a） of each subgroup（single,double and multi vessels pathological changes） were significantly higher than the levels of the control group（P〈0.05）,and Linear correlation analysis showed that the levels of hs-CRP and LP（a） were positively correlated with the severity of coronary artery stenosis.③There is no difference between elder male＇s and elder female＇ levels of hs-CRP and LP（a）（P〈0.01）.Conclusion： The relationship are positive and close between the severity of coronary artery stenosis of the elder and the levels of lipoprotein（a） and high sensitivity c-reactive protein.hs-CRP and LP（a） levels had no difference between male and female elders.