IL-6,IL-8的检测在鉴别良恶性胸水中的诊断价值分析

Differential Diagnostic Value of Determination of IL-6,IL-8 in Serum and Pleural Effusion between Benign and Malignant Hydrothorax

目的:分析检测血清、胸水中白细胞介素6(IL-6)、白细胞介素8(IL-8)水平对良恶性胸水的鉴别诊断价值。方法:采用酶联免疫吸附试验(ELISA)检测32例良性胸水患者和40例恶性胸水患者血清及胸水中IL-6、IL-8水平,以及30例健康体检者血清中IL-6、IL-8水平。结果:良性胸水组及恶性胸水组血清IL-6、IL-8水平均显著高于正常对照组,差异具有统计学意义(P<0.05);与恶性胸水组比较,良性胸水组胸水及血清中IL-6、IL-8水平升高更为显著(P<0.05),良性胸水组IL-6、IL-8的胸水/血清比值也显著高于恶性胸水组,差异具有统计学意义(P<0.05)。结论:胸水及血清中IL-6、IL-8的检测对良、恶性胸水患者具有鉴别诊断意义。

Objective：To explore the differential diagnosis value of determination of IL-6,IL-8 in serum and pleural effusion between benign and malignant hydrothora.Methods： The levels of IL-6,IL-8 in serum and pleural effusion of 32 cases with benign hydrothorax,40 cases with malignant hydrothora were detected,and the levels of IL-6,IL-8 in serum of 30 healthy subjects were detected by ELISA.Results： The levels of IL-6,IL-8 in serum were significantly increased in cases with benign or malignant hydrothora in comparison with those of control group,the difference was statistically significant（P〈0.05）.There were statistically significant differences of the levels and the pleural effusion/serum ratio of IL-6,IL-8 in serum and pleural effusion between benign and malignant hydrothora（P〉0.05）.Conclusion： The levels of IL-6,IL-8 in serum and pleural effusion may be used as an marker in the differential diagnosis of benign and malignant hydrothora.