脑膜瘤WHO分级及其基因学研究进展

This Meningioma Classification and Genetics Research Progress of the WHO

脑膜瘤是颅内第二大常见肿瘤。WHO根据组织学及肿瘤生物学将脑膜瘤分为3级。目前,随着脑膜瘤研究的深入及肿瘤分子生物学的发展,脑膜瘤在基因学方面的研究越来越受到重视。其中包括原癌基因的激活和抑癌基因的失活。现阶段,比较公认的与肿瘤包括脑膜瘤形成有关的原癌基因主要有c-myc基因、bcl-2基因、Survivin基因及mdm2基因等,抑癌基因主要有p53基因、p73基因、NF-2基因及p16基因等。这些基因通过不同的机制发生不同的改变最终参与了不同级别脑膜瘤的发生和发展。现就其研究进展做一综述。

Meningiomas is the second most common cancer in the central system.The meningioma will be divided into three levels according to the WHO histology and tumour biology.Now,along with the meningioma’s development of research and the tumor’s development of molecular biology,this meningioma in the genetic research more and more attention to.Including protocarcinogenic gene activation and tumor-suppressor gene inactivation.At present,it is recognized and tumor including meningioma form of cancer genes related the main c-myc genes,BCL-2 genes,Survivin mdm2 gene and gene,tumor suppressor genes p53 genes,p73 main gene,NF-2 gene and p16 genes,etc.These genes through the different mechanism of different change happen eventually involved in the different levels of meningiomas occurrence and development.The research progress is reviewed.