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RECK相关因子在肿瘤表达中的研究进展

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摘要 肿瘤的侵袭及远处转移是一个多因素参与,多步骤完成的非常复杂的病理过程,涉及到肿瘤血管的形成、细胞外基质及血管基底膜的降解等。实验证明,肿瘤细胞侵袭转移能力的强弱与其诱导产生的基质金属蛋白酶（matrix metalloproteinases，MMPs）降解细胞外基质及基底膜的能力密切相关，
作者 贾春霞 龚莉
机构地区 泸州医学院病理学教研室
出处 《泸州医学院学报》 2012年第2期234-236,共3页 Journal of Luzhou Medical College
关键词 肿瘤血管 相关因子 RECK 肿瘤细胞侵袭 基质金属蛋白酶 血管基底膜 细胞外基质 转移能力
分类号 R730.123.1 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Yoon SO,Park SJ,Yun CH,et al.Roles of matrie-An- chored MMP Inhibitor RECK is a key regula-tor of ex- tracellular matrix integrity and angiogenesis [J].Cell,200i 107(6): 789.
  • 2Oh J,Dias T,Wei B,et al.TIMP-2 upregulates RECK ex- pression via dephosphorylation of paxillin tyrosine residues 31 and l18[J].oncogene,2006;25(30):4230.
  • 3VT Mihaylova, tkS Bindra, J Yuan, et al.Decreased ex- pression of the DNA mismatch repair gene Mlhl under hypoxic stress in mammalian cells[J]. Mol Cell Biol,2003; 23:3265.
  • 4AX Meng, F Jalali, A Cuddihy, et al.Hypoxia down regu- lates DNA double strand break repair gene expression in prostate cancer cellslJ]. Radiother Oncol,2005;76:168.
  • 5SH. Lee, J Kim, WH. Kim, et al. Hypoxic silencing of tu- mor suppressor RUNX3 by histone modifi cation in gas- tric cancer cells[J]. Oncogene,2009;28:184.
  • 6Johnstone RW. Histone deacetylase inhibitors: novel drugs for the treatment of Cancer [J]. Nat Rev-Drug Discov, 2002;1:287.
  • 7Kyung Ju Lee,Kwang Youl Lee,You Mie Lee.Downregu- lation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-a to reverse HRE site in the promoter[J]. Biochi-mica et Biophysica Acta,2010; 1803(5):608.
  • 8Jeon HW,Lee YM.Inhibition of histone deacetylase attenuates hypoxia induced migration andinv asion of cancer cells via the restoration of RECK expression[J].Mol Cancer Ther,2010;9(5): 1361.
  • 9CaoY,LindenP,ShimaD,et al.Invivoangiogenic activity an dhypoxia induction of he- terodimets of placenta growth hctodvascular endothelial growth factor[J] .J Clin Invest, 1996;98:2507.
  • 10郑岂昌,张勇,秦涛,等.肿瘤坏死因子-α对肿瘤抑制基因RECK在HepG细胞中表达的调节作用[J].中华实验科杂志,2006;23(6):685.

二级参考文献10

  • 1季润元,冯振卿.KAI1基因与肿瘤侵袭、转移、预后的关系[J].医学研究生学报,2004,17(10):949-951. 被引量：7
  • 2Chung FL,Schwartz J,Herzog CR,et al.Tea and cancer prevention:studies in animals and humans[J].J Nutr.2003 Oct,133(10):3268S-3274S.
  • 3Takahashi C,Sheng Z,Horan TP,et al.Regulation of matrix metalloproteinase-9 and inhibition of tumor irwasion by the membrane-anchored glycoprotein RECK[J].Proc Natl Acad Sci U S A.1998 Oct 27,95(22):13221-6.
  • 4Mosmann T.Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays[J].J Immunol Methods,1983 Dec 16,65(1-2):55-63.
  • 5Yokozawa T,Nakagawa T,Kitani K.Antioxidative activity of green tea polyphenol in cholesterol-fed rats[J].J Agric Food Chem,2002 Jun 5,50(12):3549-52.
  • 6Shaw RJ,Hall GL,Lowe D,et al.CpG island methylation phenotype(CIMP)in oral cancer:associated with a marked inflammatory response and less aggressive tumour biology[J].Oral Oncol.2007 Oct,43(9):878-886.
  • 7Takahashi C,sheng Z,Horan TP,et al.Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein REOK[J].Proc Natl Acad Sci USA,1998 Oct 27,95(22):13221-13226.
  • 8Ho YC,Yang SF,Peng CY,et al.Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator[J].J Oral Pathol Med,2007 Nov,36(10):588-593.
  • 9Fang MZ,Wang Y,Ai N,et al.Tea polyphenel(-)-epigallocatechin-3-gallate inhibits DNA methyltansferase and reactivates methylation-silenced genes in cancer cell lines[J].Cancer Res,2003 Nov 15,63(22):7563-7570.
  • 10Feng Y,Wen J,Chang CC.p38 Mitogen-activated protein kinase and hematologic malignancies[J].Arch Patrol Lab Med,2009 Nov,133(11):1850-1858.

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泸州医学院学报
2012年 第2期

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