八乙基卟啉合成方法的改进

Improvement on the Synthesis of Octaethylporphyrin

以丙酰乙酸乙酯和乙酰丙酮为起始原料，经Ｋｎｏｒｒ反应制得５－甲基－３－乙基－４－乙酰基－２ 乙氧羰基吡咯（３），（３）经α位甲基的溴化和胺解得α取代胺基吡咯（４），（４）再经酸催化成环得化合物乙酰取代卟啉（５），最后使化合物（５）的乙酰基还原等五步操作合成了标题化合物，全程收率２６％

In the synthesis of octaethylporphyrin, ethyl propionylacetate and acetylacetone as the starting materials, by Knorr reaction, 5 methyl 3 ethyl 4 acetyl 2ethoxycarbonyl pyrrole (3) was obtained, Through eletrophilic substitution of bromine and amination in the pyrrolic α methyl, the α substituted aminomethyl pyrrole (4) was prepared, Through cyclization by acid catalysis acetyl porphyrin (5) was obtained. Reduction of the porphyrin lateral chain acetyl group, the title compound was synthsized. The total yield was 26%.