摘要
目的 探讨风湿性心脏病二尖瓣狭窄患者心房颤动（atrial fibrillation,AF）与血浆肾素-血管紧张素-醛固酮系统（renin-angiotensin-aldosterone system,RAAS）及内皮素-1（endothelin-1,ET-1）之间可能的关系.方法 入选风湿性心脏病中重度二尖瓣狭窄患者67例,根据患者是否伴有持续性AF分为AF组35例和窦性心律（sinus rhythm,SR）组32例;另随机选取20例健康人为正常对照组（NC组）.通过超声心动图检查评价左心房结构,放射免疫分析法（RIA）测定血浆RAAS、ET-1活性水平.结果 在二尖瓣狭窄患者中血浆肾素（renin,Ren）、血管紧张素Ⅱ（angiotensin Ⅱ,Ang Ⅱ）、醛固酮（aldosterone,ALD）及ET-1活性均明显高于NC组（P〈0.01）;AF组血浆Ang Ⅱ、ET-1均明显高于SR组（P〈0.01）,但血浆Ren、ALD在AF组和SR组之间差异无统计学意义（P〉0.05）.结论 二尖瓣狭窄患者中存在血浆RAAS、ET-1激活,伴有AF者更为显著.
Objective To investigate the possible relationship between plasma renin - angiotensin - aldosterone sys- tem （ RAAS）, endothelin - 1 （ ET - 1 ） and atrial fibrillation （AF） in patients with mitral stenosis due to rheumatic heart disease. Methods Sixty - seven patients with medium - severe mitral stenosis due to rheumatic heart disease were se- lected in this study and were assigned to AF group （ patients with permanent AF, n =- 35 ） and sinus rhythm group （ SR group, patients with SR, n =32）. Twenty normal subjects served as normal control group （NC group）. The left atrial structure was detected by color Doppler ultrasound and the plasma levels of RAAS and ET - 1 were measured by RIA. Results The plasma levels of Renin （Ren） , angiotensin ]I （ Ang 11 ） , aldosterone （ALD） , and ET - 1 in patients with mitral stenosis were all significantly higher than those in NC group （ P 〈 0.01 ） ; Compared with SR group, the plasma levels of Ang [I and ET - 1 in AF group were significantly higher （ P 〈 0.01 ）, but the plasma levels of Ren and ALD showed no statistical differences between the two groups .（ P 〉 0.05 ）. Conclusion Plasma RAAS and ET - 1 are activa- ted in patients with rheumatic mitral stenosis, and those with AF are more obvious.
出处
《徐州医学院学报》
CAS
2012年第3期172-175,共4页
Acta Academiae Medicinae Xuzhou
