局部特异性脱敏治疗常年性变应性鼻炎的免疫学观察

The immunologic study on local nasal immunotherapy for perennial allergic rhinitis

目的 :探讨鼻腔局部特异性脱敏 ( LNIT)的疗效和免疫机理。方法 :用 LNIT治疗常年性变应性鼻炎 ( PAR)患者 1 42例 ,并对其中的 30例进行免疫学观察。结果 :LNIT与传统的皮下免疫疗法的疗效相似 ( P >0 .0 5)。免疫观察表明 ,治疗后患者鼻分泌物中的 Ig A显著增加 ( P <0 .0 5) ;鼻分泌物总 Ig E、血清总 Ig E和螨、豚草的特异性 Ig E水平都有所下降 ,但仍无显著差异( P >0 .0 5)。结论 :LNIT确能通过增强局部免疫功能 ,使 PAR的治疗获得较好的效果。

Objective:To investigate the clinical efficacy and immune mechanism of local nasal immunotherapy (LNIT).Method:142 cases of perennial allergic rhinitis (PAR) were treated with LNIT.Immunologic study was carried out in 30 cases.Result:LNIT was as effective as traditional subcutaneous immunotherapy (P> 0.05 ).Immunologic study demonstrated ,that the nasal secretory IgA (S IgA) increased significantly after treatment (P< 0.05 ).The levels of nasal secretory total IgE,serum tota IgE and serum specific IgE (anti mite,ragweed pollon) decreased,but there was no significance (P> 0.05 ).Conclusion:LNIT can improve the local immune function and modify the local nasal allergic inflammatory response.It is an effective,safe and convenient treatment.