骨桥蛋白反义寡核苷酸对卵巢癌细胞HO-8910PM体外增殖的实验研究
摘要
卵巢癌是死亡率较高的妇科恶性肿瘤之一,因易转移而广泛播散,70%的患者就诊时已属晚期,因此卵巢癌的早期诊断和治疗尤其重要。许多研究提示骨桥蛋白(osteopontin,OPN)很有希望作为卵巢癌新的肿瘤标志物,进而用于卵巢癌的早期诊断和病情预测。骨桥蛋白(OPN)是一种磷酸化糖蛋白,首先由骨骼组织中分离而来,
出处
《中国实验诊断学》
2012年第4期592-594,共3页
Chinese Journal of Laboratory Diagnosis
基金
吉林省科技厅项目(20090188)
参考文献10
-
1Chabas D, Baranzini SE, Mitchell D, et al. The influence of the proinflammatory eytokine, osteopontin, on autoimmune demyelina-ting disease[J]. Science, 2001,294(5547) : 1731.
-
2Schorge JO, Drake RD, Lee H, et al. Osteopontin as an adjunct to CA125 in detecting recurrent ovarian cancer[J]. Clin Cancer Res,2004,10(10):3474.
-
3Santin AD, Zhan F, Bellone S, et al. Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy [J]. Int J Cancer, 2004,112 ( 1 ) : 14.
-
4Ye QH,Qin LX, Forgues M, et al. Predicting hepatitis B viruspositive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning [J]. Nat Med 2003,9(4):416.
-
5Khan SA,Lopez Chua CA,Zhang J,et al. Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors[J]. J Cell Biochem, 2002,85 (4) : 728.
-
6Coppola D, Szabo M, Boulware D, et al. Correlation of osteoprorein expression and pathological stage across a wide variety of variety of tumor histologies[J]. Clin Cancer Res, 2004,10:184.
-
7Rosen DG, Wang L, Atkinson JN, et al. Potential markers that complement expression of CA125 in epithelial ovarian cancer[J]. Gynecol Oneol, 2005,99 : 267.
-
80' Neill CJ, beavers MT, Malpica A, et al. An immunohistochem ical comparison between low-grade and high-grade ovarian serous earcinomas:significantly higher expression of p53, MIB1, BCL2, HER-2/neu,and C-KIT in high-grade neoplasms[J]. Am J Surg Pathol, 2005,29 : 1034.
-
9He B,Mirza M,Weber GF. An osteopontin splice variant in-duces anchorage independence in human breast cancer cells[J]. Oncogene,2006,25(15) :2192.
-
10Sodek J, Ganss B, McKee MD. Osteopontin[J]. Crit Rev Oral Biol Med,2000,11(3) :279.
-
1邹祎,杨幼易.骨桥蛋白与卵巢癌诊断的研究进展[J].医学综述,2011,17(4):533-535. 被引量:1
-
2卢小迪,莫立根.骨桥蛋白与头颈部肿瘤的研究[J].医学综述,2007,13(19):1441-1443.
-
3张毅,孙现军,智绪亭,侯文红,宋现让,姜希宏.直肠癌患者外周血骨桥蛋白的检测[J].中国现代普通外科进展,2004,7(6):376-377.
-
4张黄,杨帆,张雄.口腔鳞癌患者血清骨桥蛋白的检测及其临床意义[J].全科医学临床与教育,2008,6(1):65-66. 被引量:1
-
5雷海鸣,卞建民.骨桥蛋白与肿瘤转移[J].山西医药杂志,2007,36(9):813-815. 被引量:1
-
6杨光,张祥宏.骨桥蛋白与乳腺癌的关系及其影像学表现[J].中国医学影像学杂志,2007,15(2):142-144.
-
7任民柱(综述),杨留勤(审校).骨桥蛋白在肿瘤转移中的作用及机制[J].实用肿瘤学杂志,2010,24(2):186-189. 被引量:7
-
8李慧慧,张向宁.骨桥蛋白与卵巢恶性肿瘤相关性研究进展[J].国际妇产科学杂志,2008,35(5):335-338. 被引量:2
-
9吴绮鋆,尤永平.骨桥蛋白与胶质瘤关系的研究进展[J].医学综述,2009,15(3):321-323.
-
10都丽艳,魏芳.骨桥蛋白在卵巢肿瘤中的研究进展[J].现代肿瘤医学,2014,22(5):1209-1212. 被引量:3