空腹血糖与青年男性冠心病患者冠状动脉病变的关系

The relationship between fasting blood glucose and the severity of coronary artery lesions in young men

目的 探讨青年男性冠心病患者空腹血糖水平与冠状动脉病变程度的关系.方法 回顾性分析2009年1月至2010年12月于我院住院诊断为冠心病并行冠状动脉造影手术的青年男性（年龄≤44岁）共372例,根据冠状动脉造影结果,分为单支病变组（218例）,双支病变组（84例）和三支病变组（70例）,观察BMI、SBP、DBP、Hb、BUN、肌酐、血清尿酸、空腹血糖、TG、TC、HDL-C和LDL-C与冠状动脉病变程度的关系.结果 在单支病变、双支病变和三支病变组,空腹血糖水平逐渐升高,两两比较差异有统计学意义[分别为（6.4±2.1）、（7.5±2.5）和（8.4±3.4） mmol/L,均P＜0.05].SBP、TG、TC及HDL-C在单支病变组与其他2组比较存在统计学差异（均P＜0.05）；LDL-C在单支病变组与双支病变组比较存在统计学差异（P＜0.05）.Logistic回归分析显示,影响冠状动脉多支病变的独立危险因素为TG[4.381（1.221～15.727）]、空腹血糖[1.234（1.117 ～ 1.364）]及SBP[1.035（1.014～1.056）]（均P＜0.05）.结论 空腹血糖是青年男性冠心病患者冠状动脉多支病变的独立危险因素.

Objective To investigate fasting blood glucose and the severity of coronary artery lesions in Young men. Methods We retrospectively studied 372 young men with coronary artery disease. All patients were admitted to hospital from Jan 2009 to Dec 2010 and had coronary angiography. The clinic and coronary angiographic features were assessed. According to the result of coronary angiography, the patients were divided into three groups： the single, double and triple vessel lesions. The relation between body mass index （BMI）, systolic blood pressure （SBP）, diastolic blood pressure（ DBP）, hemoglobin（Hb）, blood urea nitrogen（ BUN）, creatinine（ Cr）, serum u- ric acid （UA）, fasting blood glucose （FBG）, triglyceride （TG）, total cholesterol（TC）, high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol （LDL-C）with severity of coronary artery disease （CAD） were observed. Results The numbers of FBG with each group were remarkably ＆fferent [ （6.4 ±2.1 ） retool/L, （ 7.5±2.5 ） mmol/L and （ 8.4± 3.4） mmol/L, respectively, all P 〈 0.05 ]. Compared with multiple vessel lesions groups, the factors in single vessel lesions such as SBP, TG, TC and HDL-C were remarkably different（ P 〈0.05 ）. Furthermore TG （ OR = 4.381 ）, FBG （ OR = 1. 234 ）, SBP （ OR = 1. 035 ） were independent risk factors （ P 〈 0.05 ） for young men with multiple vessel lesions CAD. Conclusion Fasting blood glucose is an independent risk factor of young men with multiple vessel lesions CAD.