天麻改善睡眠功能的实验研究

An experimental study of the effect of Gastrodia elata on sleeping

目的研究天麻对小鼠睡眠的改善作用。方法健康雌性昆明小鼠每天经口灌胃给予天麻(75、750和2250mg/kgBW),观察直接睡眠作用,连续给予受试物30d后进行延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验和巴比妥钠睡眠潜伏实验。结果天麻可协同戊巴比妥钠阈下剂量催眠作用(P<0.05)和缩短巴比妥钠睡眠潜伏期(P<0.01),但无延长戊巴比妥钠睡眠时间作用(P>0.05)和直接改善睡眠作用(P>0.05)。结论该天麻对小鼠具有改善睡眠功能。

Objective To study the effect of Gastrodia elata on sleeping of mice. Methods Healthy female mice were divided into three groups and orally administered with the Gastrodia elata at daily doses of 75 mg/kgBW, 750 mg/kgBW and 2 250 mg/kgBW respectively, and then the direct effect of the drugs on sleeping was observed. After 30 days of consecutive administration, the sleep-extending test with sodium pentoharhital, the sleep-producing test with sub threshold dose of sodium pentobarbital, and the sleep incubation period test with sodium barbital were conducted. Results The Gastrodia elata had effects on sleep-producing action of sodium pentobarbital at sub-threshold dose （P 〈 0. 05） and significantly shorten the incubation period induced by sodium barbital （P 〈 0.01 ）. But the direct sleeping effect of Gastrodia capsules （P 〉 0. 05 ） and its effect on prolonging sleeping time with sodium pentobarbital were not observed （ P 〉 0.05 ）. Conclusion The Gastrodia elata could improve the sleep quality of mice to a certain degree.