丹红治疗急性脑梗死的临床研究

Observation of Combination of Danhong Injection and Aspirine Therapy in Treating Patients with Cerebral Infarction

目的探讨丹红治疗急性脑梗死的疗效和安全性。方法 92例脑梗死患者,随机分为治疗组(n=46例)和对照组(n=46例),分别给予减轻脑水肿药物和脑保护剂,同时口服阿司匹林;治疗组在此基础上加用丹红注射液。分别于治疗前、治疗后第7、14、21和28天进行神经功能缺损情况和病情程度。结果 2组患者在用药后第7、14、21和28天神经功能缺损评分和日常生活活动Barthel指数与前一观察日的差异均有统计学意义(P<0.05)。与对照组比较,治疗组患者神经功能恢复早,在用药后第21、28天差异有显著性(P<0.05)。两组用药后无明显不良反应。结论丹红注射液联合阿司匹林治疗脑梗死疗效确切,安全性好。

Objective To evaluate efficacy of combining therapy of Danhong injection together with aspirin in patients with acute cerebral infarction.Methods Patients with cerebral infarction（n=92） were allocated into two groups randomly combination group（n=46） and controlled group（n=46）,and were given the drugs of relieving brain edema and protecting brain respectively and at the time oral aspirin as well;while,the combination group were given,aside from those mentioned above,Danhong injection.Observation on clinical neuro-functional disorder and severity was carried out before treatment and after treatment on the seventh,fourteenth,twenty-first and twenty-eighth day.Results According to the Chinese Stroke Scale and the Barthel Score,we found that there were definite effectiveness and statistical significances in the patients of the two groups after the treatment on the 7th,14th,21st,28 th,compared with those prior to the treatment.There were also significant differences between the two groups regarding the efficacies of Danhong and aspirine miltiorrhiza on the 21st and 28th day（P〈0.05）,and the improvement based on Chinese Stroke Scale and the Barthel Score,came earlier and proved more effective in the combination group since the 2nd day.Adverse reactions were modest in all patients.Conclusion Combination of Danhong injection and aspirin is effective and safe in the treatment of acute cerebral infarction.