CD133及Notch1基因在上皮性卵巢癌中的表达和临床病理意义

Expressions of CD133 and Notch1 in epithelial ovarian cancers and their relationships with clinicopathologic characteristics

目的探讨卵巢癌组织中CD133及Notch1的表达及其临床意义。方法采用免疫组化SP法检测46例上皮性卵巢癌组织、18例良性上皮性卵巢肿瘤组织及10例正常卵巢组织中CD133及Notch1的表达情况。结果正常卵巢组织、良性上皮性卵巢肿瘤组织及卵巢癌组织中CD133及Notch1的表达呈升高趋势,组间比较有显著性差异。CD133及Notch1表达水平与卵巢癌的分期、病理分级及淋巴结转移相关,而与年龄及组织类型无关。Spearman相关性分析显示CD133表达与Notch1的表达呈正相关。结论 CD133及Notch1的高表达可能与卵巢癌的发生、发展有关。

Objective It is to investigate the expressions of CD133 and Notch l and their correlations with the clinieopathological feature in epithelial ovarian cancers. Methods CD133 and Notchl protein levels were detected in 46 cases of epthelial ovarian cancer, 18 cases of benign ovarian tumor and 10 cases of normal ovarian tissues by immunohistochemistry. Results The positive expression rates of CD133 and Notchl protein in normal ovarian tissues, benign ovarian tumor and epthelial ovarian cancer were gradually increased, the statistical difference was significant （P 〈 0. 001 ）. The expression of CD133 and Notchl protein were related to ovarian cancer stage, differentiation degree and lymph node metastasis, but they were not corre- lated with patient＇ s age and histological subtype. In addition, the expression of CD133 protein was positively related to that of N otchl protein（ r = 0. 401,P 〈 0.05 ）. Conclusion Over-expression of CD133 and Notch l protein play an important role in the development of ovarian cancer.