新生儿尿布皮炎联合给药对经皮渗透影响的实验研究

Impact of drug co-administration on in vitro percutaneous permeation: animal experimental study on neonatal diaper dermatitis

目的探讨联合给药治疗新生儿尿布皮炎对药物经皮渗透指标的影响。方法以家兔为研究模型,分成三组,每组8只,分别进行单独应用氧化锌油、制霉菌素及两种药物联合应用的体外经皮渗透实验。测定三组经皮渗透量、渗透速率及滞后时间等渗透指标。结果氧化锌组与混合用药组氧化锌的经皮渗透指标比较,差异无统计学意义(均P>0.05);制霉菌素组与混合用药组中制霉菌素的经皮渗透指标比较,差异有统计学意义(均P<0.01)。结论氧化锌与制霉菌素混合用药中制霉菌素的渗透率低于单一应用制霉菌素。氧化锌油与制霉菌素联合应用时应采用交叉给药,混合给药干扰制霉菌素的经皮渗透效果。

Objective To explore the impact of drug co-administration for the treatment of neonatal diaper dermatitis on in vitro percutaneous permeation. Methods Twenty-four rabbits were randomly and commensurately assigned to three groups and treated as in vitro model for percutaneous permeation.Zinc oxide oil,nystatin,and co-administration of the two drugs were given to the 3 groups respectively.Permeation parameters such as permeation amount,permeation rate,and permeation lag time were measured. Results There were no significant differences in the above 3 permeation parameters between the zinc oxide group and the co-administration group（P〉0.05 for all）,however statistically significant differences were found between the nystatin group and the co-a-dministration group（P〈0.01 for all）. Conclusion Co-administration of zinc oxide oil and nystatin may decrease percutaneous permeation of nystatin than administration of nystatin alone.Cross-administration of zinc oxide oil and nystatin is recommended when the two drugs are used in combination for treatment.Co-administration reduces percutaneous permeation of nystatin.