全真一气汤对肾不纳气证COPD模型大鼠甲状腺、肾上腺、性腺激素水平的影响

Effect of Quanzhen Yiqi Decoction on hormone from thyroid,adrenal and hebin in blood serum from COPD-Rats cast of kidney failing to promote inspiration

目的:探讨全真一气汤对肾不纳气证慢性阻塞性肺疾病(COPD)模型大鼠甲状腺、肾上腺、性腺激素水平的影响。方法:SO2熏吸+腺嘌呤饲料饲养复制肾不纳气证COPD大鼠模型。中药组用全真一气汤进行治疗,西药组用氨茶碱治疗,实验结束后对照观察大鼠血清中的甲状腺激素、皮质醇、性激素含量差异。结果:与西药组、模型组比较,中药组大鼠血清中的甲状腺激素、皮质醇、性激素含量明显升高(P<0.05,P<0.01)。结论:全真一气汤可调节下丘脑—垂体—甲状腺、肾上腺、性腺轴功能,从而起到补肾纳气的效果。

Objective： To explore the effect of Quanzhen Yiqi Decoction on hormone from thyroid, adrenal and hebin in blood serum from COPD-rats cast of kidney failing to promote inspiration. Methods： To make a copy of COPD-Rats cast of kidney failing to promote inspiration by SO2 to smoke＋adenine diet.Chinese medicines group was treated with Quanzhenyiqi Decoction, and westem medicines group with aminophylline. To observe the difference of thyroid hormones, cortisol and sex hormones in blood serum at last. Results： Compared to western medicines group and model group, content of hormones of Chinese medicines group is advanced（P〈0.05, P〈0.01）. Conclusion： Quanzhen Yiqi Decoction can regulate the functions of hypothalamic-pituitary-（thyroid, adrenal, gonads）, that to some degree aim directly at kidney essence in traditional chinese medicine（TCM）, bringing improving inspiration by invigorating the kidney into full play.